Budreckis D M, Byrne B A, Pollard R E, Rebhun R B, Rodriguez C O, Skorupski K A
Veterinary Medical Teaching Hospital, Center for Companion Animal Health, University of California, Davis, CA.
Department of Clinical Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA.
J Vet Intern Med. 2015 May-Jun;29(3):828-33. doi: 10.1111/jvim.12578. Epub 2015 May 1.
Urinary tract infections (UTI) are believed to be common in dogs with transitional cell carcinoma (TCC), but incidence and contributing factors have not been reported.
To determine the frequency and bacterial agents associated with UTI in dogs with TCC and define contributing factors.
Eighty-five dogs with a history of urogenital TCC undergoing treatment with chemotherapy that had at least 1 urine culture performed.
Medical records and culture results were retrospectively reviewed and ultrasound images were reviewed when available. Clinical factors were evaluated statistically for association with positive culture.
Fifty-five percent (47/85) of dogs had at least 1 positive culture during the course of treatment. Female dogs (80%, 40/50) were more likely than male dogs (29%, 10/35) to have at least 1 positive culture. Ultrasound examination determined that female dogs were more likely to have urethral (74%, 31/42) or trigonal tumor involvement (71%, 30/42) compared to male dogs (32%, 9/28 and 43%, 12/28, respectively). The most commonly isolated organisms were Staphylococcus spp. (23.9%, 29/121) and Escherichia coli (19.8%, 24/121). Dogs with urethral involvement of TCC were significantly more likely to have at least 1 positive culture than dogs without urethral involvement (75%, 30/40 versus 30%, 9/30).
Urinary tract infection is common in dogs with TCC highlighting the importance of regular monitoring for bacterial cystitis in dogs with TCC. In addition, clinical factors such as tumor location and sex may be predictive of positive culture and can help clinicians assess the risk of UTI.
人们认为，患有移行细胞癌（TCC）的犬只中尿路感染（UTI）很常见，但发病率及相关因素尚未见报道。
确定患有TCC的犬只中UTI的发生频率及相关细菌病原体，并明确相关因素。
85只曾接受化疗且至少进行过1次尿液培养的有泌尿生殖系统TCC病史的犬只。
对病历和培养结果进行回顾性分析，如有超声图像也一并回顾。对临床因素进行统计学评估，以确定其与培养阳性结果的相关性。
55%（47/85）的犬只在治疗过程中至少有1次培养结果呈阳性。雌性犬只（80%，40/50）比雄性犬只（29%，10/35）更易出现至少1次培养结果呈阳性。超声检查发现，与雄性犬只（分别为32%，9/28和43%，12/28）相比，雌性犬只更易出现尿道（74%，31/42）或膀胱三角区肿瘤累及（71%，30/42）。最常分离出的病原体是葡萄球菌属（23.9%，29/121）和大肠杆菌（19.8%，24/121）。TCC累及尿道的犬只比未累及尿道的犬只更易出现至少1次培养结果呈阳性（75%，30/40对30%，9/30）。
UTI在患有TCC的犬只中很常见，这凸显了对患有TCC的犬只定期监测细菌性膀胱炎的重要性。此外，肿瘤位置和性别等临床因素可能预示培养结果呈阳性，并有助于临床医生评估UTI风险。
