Griffin Maureen A, Culp William T N, Rebhun Robert B
School of Veterinary Medicine, University of California-Davis, 1 Garrod Drive, Davis, CA 95616, USA.
Vet Sci. 2018 Nov 27;5(4):96. doi: 10.3390/vetsci5040096.
Lower urinary tract neoplasia in companion animals is a debilitating and often life-threatening disease. Tumors of the bladder, urethra, and prostate often occur independently, although extension of these tumors into adjacent regions of the lower urinary tract is documented frequently. The most common lower urinary tract tumor in dogs and cats is transitional cell carcinoma (TCC). In both dogs and cats, TCC affecting the urinary bladder is generally considered to be highly aggressive with both local and metastatic disease potential, and this disease poses unique treatment challenges. Whereas much literature exists regarding the TCC disease process, treatment options, and prognosis in dogs, relatively few studies on feline TCC have been published due to the lower incidence of TCC in this species. Prostate tumors, most commonly adenocarcinomas, occur less commonly in dogs and cats but serve an important role as a comparative model for prostate neoplasia in humans. This article serves as a review of the current information regarding canine and feline lower urinary tract neoplasia as well as the relevance of these diseases with respect to their human counterparts.
伴侣动物下泌尿道肿瘤是一种使人虚弱且往往危及生命的疾病。膀胱、尿道和前列腺的肿瘤通常独立发生，不过这些肿瘤向邻近下泌尿道区域的蔓延情况常有记录。犬猫最常见的下泌尿道肿瘤是移行细胞癌（TCC）。在犬和猫中，影响膀胱的TCC通常被认为具有高度侵袭性，兼具局部和转移疾病的可能性，并且这种疾病带来了独特的治疗挑战。尽管有大量关于犬TCC疾病进程、治疗选择和预后的文献，但由于该物种中TCC发病率较低，关于猫TCC的研究相对较少。前列腺肿瘤，最常见的是腺癌，在犬猫中较少见，但作为人类前列腺肿瘤的比较模型发挥着重要作用。本文旨在综述有关犬猫下泌尿道肿瘤的当前信息，以及这些疾病与其人类对应疾病的相关性。
