Department of Primary Care and Public Health, Imperial College London, UK.
Addiction. 2012 Feb;107(2):323-30. doi: 10.1111/j.1360-0443.2011.03596.x. Epub 2011 Oct 26.
To determine the performance of subjectively defined intoxications, hangovers and alcohol-induced pass-outs in identifying drinkers at risk for adverse health outcomes.
Prospective population-based cohort study.
Working-aged Finnish general population.
A total of 21,204 alcohol-drinking men and women aged 20-24, 30-34, 40-44 and 50-54 years at baseline who participated in the Health and Social Support (HeSSup) postal survey in 1998.
Binge drinking was measured by subjectively defined intoxications/drunkenness, hangovers and alcohol-induced pass-outs. Hazardous drinking was defined according to Finnish guidelines as weekly total intake of >287 g of ethanol for men, and for women > 191 g of ethanol (≥24 and ≥16 standard drinks, respectively). Study participants were followed-up for 7 years for alcohol-specific hospitalizations and deaths. Proportional hazard models and areas under the receiver operating characteristics curves (AUC) were used to analyse the data.
Of the drinkers, 6.5% exceeded the weekly limit for hazardous drinking, and 1.5% experienced the alcohol-specific end-point during the follow-up. Subjective intoxications, hangovers and alcohol-induced pass-outs all predicted future alcohol-specific diagnoses independently of average intake and of several other potential confounders. In identifying baseline hazardous drinking, subjective intoxications had a superior performance in relation to other subjective measures of binge drinking. In identifying future alcohol-specific hospitalizations or death, subjective intoxications had also the best performance, but this was not significantly different from the other binge drinking measures, or average intake.
Subjectively defined intoxications, hangovers and alcohol-induced pass-outs are population-level proxy measures of at-risk drinking patterns.
确定主观定义的醉酒、宿醉和酒精引起的昏迷在识别有不良健康后果风险的饮酒者方面的表现。
前瞻性基于人群的队列研究。
芬兰工作年龄的普通人群。
共有 21204 名年龄在 20-24、30-34、40-44 和 50-54 岁的饮酒男女，他们在 1998 年参加了健康和社会支持（HeSSup）的邮寄调查。
狂饮通过主观定义的醉酒/醉酒、宿醉和酒精引起的昏迷来衡量。危险饮酒根据芬兰指南定义为每周总摄入量男性>287 克乙醇，女性>191 克乙醇（分别为≥24 和≥16 标准饮料）。研究参与者随访 7 年，以确定与酒精相关的住院和死亡情况。使用比例风险模型和接收器操作特性曲线下的面积（AUC）分析数据。
在饮酒者中，6.5%超过了危险饮酒的每周限量，1.5%在随访期间经历了特定于酒精的终点。主观醉酒、宿醉和酒精引起的昏迷都能独立于平均摄入量和其他几个潜在的混杂因素预测未来的酒精特异性诊断。在确定基线危险饮酒时，主观醉酒在识别狂饮方面的表现优于其他主观测量方法。在识别未来的酒精特异性住院或死亡方面，主观醉酒也有最佳表现，但与其他狂饮测量方法或平均摄入量相比，没有显著差异。
主观定义的醉酒、宿醉和酒精引起的昏迷是有风险的饮酒模式的人群水平替代指标。
