O'Neill P A, Faragher E B, Davies I, Wears R, McLean K A, Fairweather D S
Department of Geriatric Medicine, University Hospital of South Manchester.
Age Ageing. 1990 Jan;19(1):68-71. doi: 10.1093/ageing/19.1.68.
The results reported here are from a 2-year follow-up study of 58 elderly patients in a continuing-care unit. Most of these patients were in a hyperosmolar state at the time of entry (mean plasma osmolality 304 +/- 8 mOsmol/kg). The survival of those patients with the highest osmolality (greater than 308 mOsmol/kg) was significantly reduced (p = 0.025), with an increased mortality at 2 years (15/20 patients, p = 0.053). There was no correlation between age and plasma osmolality (r = 0.02) and the effect of osmolality on survival was independent of age. Hyperosmolality was either a marker for, or a cause of, increased mortality in this group of frail elderly patients.
本文报告的结果来自对一家持续护理机构中58名老年患者进行的为期2年的随访研究。这些患者大多数在入院时处于高渗状态（平均血浆渗透压为304±8 mOsmol/kg）。渗透压最高（大于308 mOsmol/kg）的患者生存率显著降低（p = 0.025），2年时死亡率增加（20名患者中有15名，p = 0.053）。年龄与血浆渗透压之间无相关性（r = 0.02），渗透压对生存的影响与年龄无关。在这群体弱的老年患者中，高渗状态要么是死亡率增加的一个指标，要么是其一个原因。
