McLean K A, O'Neill P A, Davies I, Morris J
Department of Geriatric Medicine, University Hospital of South Manchester.
Age Ageing. 1992 Jan;21(1):56-60. doi: 10.1093/ageing/21.1.56.
We have shown an age-associated increase in plasma osmolality (p less than 0.001) in 152 randomly selected subjects, living in the community. In the old [mean age 78.0 (7.5) years] the plasma osmolality was 302.2 (300.6-303.8) mOsmol/kg compared with 291.2 (290.0-292.3) mOsmol/kg in the young [39.2 (11.2) years] (p less than 0.0001). In a further group of 20 screened, health status defined, elderly subjects the plasma osmolality was 298.1 (295.9-300.3) mOsmol/kg, which was significantly higher than the young group (p less than 0.0001) but lower than the unscreened old subjects (p = 0.005). The variance was also significantly lower (p = 0.03). The results may reflect a loosening of homoeostatic control and highlight the need for care in subject selection in studies of ageing.
我们对152名随机挑选的社区居民进行研究，结果显示血浆渗透压随年龄增长而升高（p<0.001）。老年人[平均年龄78.0（7.5）岁]的血浆渗透压为302.2（300.6 - 303.8）mOsmol/kg，而年轻人[39.2（11.2）岁]为291.2（290.0 - 292.3）mOsmol/kg（p<0.0001）。在另一组经过筛选、健康状况明确的20名老年受试者中，血浆渗透压为298.1（295.9 - 300.3）mOsmol/kg，显著高于年轻组（p<0.0001），但低于未筛选的老年受试者（p = 0.005）。方差也显著更低（p = 0.03）。这些结果可能反映了稳态控制的松弛，并突出了在衰老研究中进行受试者选择时需谨慎的必要性。
