Fritschi Lin, Tabrizi Jafar, Leavy Justine, Ambrosini Gina, Timperio Anna
Western Australian Institute for Medical Research, University of Western Australia, Australia.
Public Health. 2007 Oct;121(10):781-9. doi: 10.1016/j.puhe.2007.01.011. Epub 2007 May 30.
To determine the relationship between personal, hormonal and lifestyle risk factors and surgically treated benign prostatic hyperplasia (BPH).
A population-based case-control study was conducted in Western Australia (WA) on men aged 40-75 years who were surgically treated at public and private hospitals for BPH during 2001-2002. Controls were recruited from the WA electoral roll. Cases and controls were compared with regard to demographic and lifestyle factors and proxy measures of hormonal status using logistic regression. Data were available for 398 cases and 471 controls.
No associations with BPH were found for family history of prostate cancer in father or brother, serving in the military in a combat area, pattern of baldness, smoking status, obesity, alcohol intake and occupational physical activity. The only inverse relationship was observed with heavy alcohol drinking (>30g/day), however, this was not statistically significant. An increased risk of BPH, not statistically significant, was observed for British-born men compared to Australian born and for history of vasectomy. The analysis was repeated after excluding 28% of controls with moderate and severe symptoms of BPH and 7% of cases with mild symptoms prior to surgery, and our results remained essentially unchanged.
The results suggest that there are few risk factors for BPH although perhaps country of birth, vasectomy and heavy alcohol consumption may be considered further.
确定个人、激素及生活方式风险因素与手术治疗的良性前列腺增生（BPH）之间的关系。
在西澳大利亚（WA）对40 - 75岁男性进行了一项基于人群的病例对照研究，这些男性在2001 - 2002年期间在公立和私立医院接受了BPH手术治疗。对照组从WA选民名册中招募。使用逻辑回归比较病例组和对照组在人口统计学和生活方式因素以及激素状态替代指标方面的差异。共有398例病例和471例对照的数据可供分析。
未发现父亲或兄弟患前列腺癌家族史、在战区服兵役、脱发模式、吸烟状况、肥胖、饮酒量和职业体力活动与BPH有关。仅观察到与大量饮酒（>30克/天）存在负相关关系，然而，这在统计学上并不显著。与澳大利亚出生的男性相比，英国出生的男性以及有输精管切除术史的男性患BPH的风险增加，但差异无统计学意义。在排除28%有中度和重度BPH症状的对照组以及7%术前有轻度症状的病例组后重复进行分析，结果基本保持不变。
结果表明，BPH的风险因素较少，尽管出生国家、输精管切除术和大量饮酒可能需要进一步研究。
