Centro de Investigación del Cáncer/IBMCC (USAL/CSIC), Departamento de Medicina and Servicio General de Citometría, University of Salamanca, 37007 Salamanca, Spain.
Eur J Pharm Sci. 2012 Mar 12;45(4):499-506. doi: 10.1016/j.ejps.2011.07.009. Epub 2011 Jul 22.
The field of proteomics has undergone rapid advancements over the last decade and protein microarrays have emerged as a promising technological platform for the challenging tasks of studying complex proteomes. Researchers have gone beyond traditional techniques and approached promising disciplines like nanotechnology to satisfy the growing demands of studying proteins in high-throughput format. Applications of nanotechnology in proteomics came from the need to detect low-abundant proteins in complex mixtures for sensitive, real-time and multiplexed detection platform. The scope of this article is to outline the current status and key technological advances of nanotechniques in protein microarrays.
在过去的十年中，蛋白质组学领域取得了快速发展，蛋白质微阵列已经成为研究复杂蛋白质组学的有前途的技术平台。研究人员已经超越了传统技术，并采用了有前途的纳米技术等学科，以满足高通量格式研究蛋白质的不断增长的需求。纳米技术在蛋白质组学中的应用源于在复杂混合物中检测低丰度蛋白质的需求，以实现敏感、实时和多重检测平台。本文的范围是概述纳米技术在蛋白质微阵列中的当前现状和关键技术进展。
