Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, People’s Republic of China.
Biol Pharm Bull. 2011;34(8):1194-7. doi: 10.1248/bpb.34.1194.
Oxidative damage plays a critical role in many neurodegenerative diseases. Astrocytes are involved in supporting the survival and protection of neurons against oxidative damage. The dysfunction of antioxidant in astrocytes has been implicated in a variety of neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), spinalmuscularatrophy (SMA). The loss of motor neuron in spinal cord has been attributed to deterioration of astrocytes. The activation of antioxidantive function in astrocytes may serve as a therapeutic strategy for neurodegenerative diseases. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master transcriptional regulator of phase II antioxidantive genes. We report herein that curcumin significantly activates Nrf2 target genes in primary spinal cord astrocytes, decreases the level of intracellular reactive oxygen species (ROS), and attenuates oxidative damage and mitochondrial dysfunction.
氧化损伤在许多神经退行性疾病中起着关键作用。星形胶质细胞参与支持神经元的存活和保护，使其免受氧化损伤。星形胶质细胞中抗氧化剂的功能障碍与多种神经退行性疾病有关，如肌萎缩侧索硬化症（ALS）、脊髓性肌萎缩症（SMA）。脊髓中运动神经元的丧失归因于星形胶质细胞的恶化。激活星形胶质细胞中的抗氧化功能可能是神经退行性疾病的一种治疗策略。核因子红细胞 2 相关因子 2（Nrf2）是 II 相抗氧化基因的主要转录调节因子。我们在此报告，姜黄素可显著激活原代脊髓星形胶质细胞中的 Nrf2 靶基因，降低细胞内活性氧（ROS）水平，并减轻氧化损伤和线粒体功能障碍。
