克拉迪尤尼西林A - E，源自印度尼西亚软珊瑚Cladiella sp.的新型尤尼西林类化合物

Cladieunicellins A-E, new eunicellins from an Indonesian soft coral Cladiella sp.

作者信息

Chen Yung-Husan, Tai Chia-Ying, Kuo Yueh-Hsiung, Kao Chia-Ying, Li Jan-Jung, Hwang Tsong-Long, Fang Lee-Shing, Wang Wei-Hsien, Sheu Jyh-Horng, Sung Ping-Jyun

机构信息

National Museum of Marine Biology and Aquarium, Pingtung, Taiwan.

出版信息

Chem Pharm Bull (Tokyo). 2011;59(3):353-8. doi: 10.1248/cpb.59.353.

DOI:10.1248/cpb.59.353

PMID:21372417

Abstract

Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.

摘要

从一种鉴定为Cladiella sp.的印度尼西亚软珊瑚中分离出了五种新的海松素型二萜类化合物，即枝状海松素A - E（1 - 5）。通过光谱方法确定了二萜类化合物1 - 5的结构。发现海松素2和5分别对DLD - 1和HL - 60肿瘤细胞具有细胞毒性，并且3对人中性粒细胞产生超氧阴离子具有抑制作用。