Florea Ana-Maria, Büsselberg Dietrich
Department of Neuropathology, Heinrich-Heine University, 40225 Düsseldorf, Germany.
J Toxicol. 2011;2011:159619. doi: 10.1155/2011/159619. Epub 2011 Jul 24.
Metals and metal compounds are part of our environment. Several metals are essential for physiological functions (e.g., zinc or magnesium); while the beneficial effects of others are uncertain (e.g., manganese), some metals are proven to be toxic (e.g., mercury, lead). Additionally there are organic metal compounds; some of them are extremely toxic (e.g., trimethyltin, methylmercury), but there is very little knowledge available how they are handled by organisms. Scientific evidence indicates that long-term exposure to (some) metallic compounds induces different forms of cancer, including breast cancer. On the other side, several metal compounds have clinical use in treating life-threatening diseases such as cancer. In this paper we discuss the recent literature that shows a correlation between metal exposure and breast cancer.
金属和金属化合物是我们环境的一部分。几种金属对生理功能至关重要（例如锌或镁）；而其他一些金属的有益作用尚不确定（例如锰），一些金属已被证明具有毒性（例如汞、铅）。此外还有有机金属化合物；其中一些毒性极强（例如三甲基锡、甲基汞），但关于生物体如何处理它们的知识却非常有限。科学证据表明，长期接触（某些）金属化合物会诱发不同形式的癌症，包括乳腺癌。另一方面，几种金属化合物在治疗诸如癌症等危及生命的疾病方面有临床应用。在本文中，我们讨论了最近显示金属暴露与乳腺癌之间存在关联的文献。
