Eder Anne F, Dy Beth A, Kennedy Jean M, Notari Iv Edward P, Strupp Annie, Wissel Mary Ellen, Reddy Ramakrishna, Gibble Joan, Haimowitz Marcia D, Newman Bruce H, Chambers Linda A, Hillyer Christopher D, Benjamin Richard J
Biomedical Services, Medical Office, National Headquarters, American Red Cross, Washington, DC, USA.
Transfusion. 2008 Sep;48(9):1809-19. doi: 10.1111/j.1537-2995.2008.01811.x. Epub 2008 Jul 9.
The American Red Cross (ARC) initiated a comprehensive donor hemovigilance program in 2003. We provide an overview of reported complications after whole blood (WB), apheresis platelet (PLT), or automated red cell (R2) donation and analyze factors contributing to the variability in reported complication rates in our national program.
Complications recorded at the collection site or reported after allogeneic WB, apheresis PLT, and R2 donation procedures in 36 regional blood centers in 2006 were analyzed by univariate and multivariate logistic regression.
Complications after 6,014,472 WB, 449,594 PLT, and 228,183 R2 procedures totaled 209,815, 25,966, and 12,282 (348.9, 577.5, and 538.3 per 10,000 donations), respectively, the vast majority of which were minor presyncopal reactions and small hematomas. Regional center, donor age, sex, and donation status were independently associated with complication rates after WB, PLT, and R2 donation. Seasonal variability in complications rates after WB and R2 donation correlated with the proportion of donors under 20 years old. Excluding large hematomas, the overall rate of major complications was 7.4, 5.2, and 3.3 per 10,000 collections for WB, PLT, and R2 procedures, respectively. Outside medical care was recorded at similar rates for both WB and automated collections (3.2 vs. 2.9 per 10,000 donations, respectively).
The ARC data describe the current risks of blood donation in a model multicenter hemovigilance system using standardized definitions and reporting protocols. Reported reaction rates varied by regional center independently of donor demographics, limiting direct comparison of different regional blood centers.
美国红十字会（ARC）于2003年启动了一项全面的献血者血液监测计划。我们概述了全血（WB）、单采血小板（PLT）或自动采集红细胞（R2）捐献后报告的并发症情况，并分析了导致我们国家计划中报告的并发症发生率存在差异的因素。
对2006年36个地区血液中心在采集现场记录的或在异体全血、单采血小板和R2捐献程序后报告的并发症进行单因素和多因素逻辑回归分析。
6014472次全血、449594次血小板和228183次R2程序后的并发症分别为209815例、25966例和12282例（每10000次捐献分别为348.9例、577.5例和538.3例），其中绝大多数是轻微的晕厥前反应和小血肿。地区中心、献血者年龄、性别和献血状态与全血、血小板和R2捐献后的并发症发生率独立相关。全血和R2捐献后并发症发生率的季节性变化与20岁以下献血者的比例相关。排除大血肿后，全血、血小板和R2程序每10000次采集的主要并发症总体发生率分别为7.4例、5.2例和3.3例。全血和自动采集的外部医疗护理记录率相似（分别为每10000次捐献3.2例和2.9例）。
ARC的数据使用标准化定义和报告协议描述了模型多中心血液监测系统中当前的献血风险。报告的反应率因地区中心而异，与献血者人口统计学无关，限制了不同地区血液中心之间的直接比较。
