Hulley S, Ashman P, Kuller L, Lasser N, Sherwin R
Lipids. 1979 Jan;14(1):119-123. doi: 10.1007/BF02533580.
Preliminary data from the Multiple Risk Factor Intervention Trial (MRFIT) have been examined for evidence that the program has an influence on plasma HDL-cholesterol. The overall mean level of this lipoprotein in the initial cohort of 1,084 men was not altered by two years of participation in this risk factor reduction project. However, changes did occur, both upwards and downwards, in some individuals. There were significant negative associations between change in HDL-cholesterol and changes in body mass, VLDL-cholesterol, LDL-cholesterol, and serum thiocyanate (a measure of cigarette smoking exposure); and there was a small positive association with change in reported alcohol intake. Multiple regression analysis revealed each of these associations to be independent of the others. The fat-controlled diet designed to lower total serum cholesterol did not decrease HDL-cholesterol levels. We conclude that conventional risk reduction programs are not likely to lower circulating HDL-cholesterol, and that program components such as weight reduction and smoking cessation may increase the levels.
对多重危险因素干预试验（MRFIT）的初步数据进行了检查，以寻找该项目对血浆高密度脂蛋白胆固醇（HDL-胆固醇）有影响的证据。在最初的1084名男性队列中，参与这个降低危险因素项目两年后，这种脂蛋白的总体平均水平并未改变。然而，一些个体确实出现了HDL-胆固醇水平的升高或降低。HDL-胆固醇的变化与体重、极低密度脂蛋白胆固醇（VLDL-胆固醇）、低密度脂蛋白胆固醇（LDL-胆固醇）以及血清硫氰酸盐（衡量吸烟暴露程度的指标）的变化之间存在显著的负相关；与报告的酒精摄入量变化之间存在微弱的正相关。多元回归分析表明，这些关联相互独立。旨在降低总血清胆固醇的脂肪控制饮食并未降低HDL-胆固醇水平。我们得出结论，传统的降低危险因素项目不太可能降低循环中的HDL-胆固醇水平，而减肥和戒烟等项目组成部分可能会提高其水平。
