海洋来源链霉菌产生的 Chromomycin SA 类似物
Chromomycin SA analogs from a marine-derived Streptomyces sp.
机构信息
Department of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.
出版信息
Bioorg Med Chem. 2011 Sep 1;19(17):5183-9. doi: 10.1016/j.bmc.2011.07.013. Epub 2011 Jul 20.
Abstract
Two chromomycin SA analogs, chromomycin SA(3) and chromomycin SA(2), along with deacetylchromomycin A(3) and five previously reported chromomycin analogs were isolated from a marine-derived Streptomyces sp. The structures of the new compounds were determined by spectroscopic methods including 1D and 2D NMR techniques, HRMS and chemical methods. Chromomycin SA(3) and chromomycin SA(2) are the first naturally occuring chromomycin analogs with truncated side-chains. Biological evaluation of chromomycin analogs for cytotoxicity against two non-small cell lung cancer (NSCLC) cell-lines, A549 and HCC44, demonstrated a decrease in cytotoxicity for the truncated sides chain chromomycin analogs.
摘要
从海洋来源的链霉菌中分离得到两种柔红霉素 SA 类似物，柔红霉素 SA(3)和柔红霉素 SA(2)，以及去乙酰柔红霉素 A(3)和五种先前报道的柔红霉素类似物。新化合物的结构通过包括 1D 和 2D NMR 技术、高分辨率质谱和化学方法在内的光谱方法确定。柔红霉素 SA(3)和柔红霉素 SA(2)是具有截断侧链的第一个天然存在的柔红霉素类似物。对两种非小细胞肺癌 (NSCLC) 细胞系 A549 和 HCC44 的细胞毒性进行的柔红霉素类似物的生物学评价表明，截断侧链柔红霉素类似物的细胞毒性降低。
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