FBXW5 控制着中心体的数量。
FBXW5 controls centrosome number.
出版信息
Nat Cell Biol. 2011 Aug 1;13(8):888-90. doi: 10.1038/ncb2312.
Abstract
Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication.
摘要
细胞周期中防止中心体过度复制的调控机制尚未完全阐明。本期文章表明，FBXW5 可控制中心体组装因子 HsSAS-6 的降解。此外，该研究还提出 FBXW5 是 PLK4 和 APC/C 的底物，而这两者是中心体复制的两个公认的调控因子。
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本文引用的文献
1
The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.SCF-FBXW5 E3-泛素连接酶受 PLK4 调控，靶向 HsSAS-6 以控制中心体复制。
Nat Cell Biol. 2011 Jul 3;13(8):1004-9. doi: 10.1038/ncb2282.
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Structural basis of the 9-fold symmetry of centrioles.中心体 9 重对称结构的基础。
Cell. 2011 Feb 4;144(3):364-75. doi: 10.1016/j.cell.2011.01.008.
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Structures of SAS-6 suggest its organization in centrioles.SAS-6 的结构表明其在中心体中的组织方式。
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Cep152 interacts with Plk4 and is required for centriole duplication.CEP152 与 Plk4 相互作用，对于中心体复制是必需的。
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SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.SCF（细胞周期蛋白 F）通过降解 CP110 来控制中心体稳态和有丝分裂保真度。
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Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation.Plk4 转位自磷酸化通过控制βTrCP 介导的降解来调节中心体数量。
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7
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