Saraf Swarnlata, Sahu Sneha, Kaur Chanchal Deep, Saraf Shailendra
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh-492 010, India.
Pharmacognosy Res. 2010 May;2(3):146-51. doi: 10.4103/0974-8490.65508.
Improvements of skin hydration properties by the use of polyherbal moisturizers are the recent advances in cosmetic preparations to avoid the harmful effects of chemical moisturizers. The main aim of the study was to establish selection preference of different available marketed herbal moisturizers on the basis of the efficiency of constituents for their hydration effects. The criteria for the selection of formulations were presence of herbal constituents, wheat germ oil and Aloe vera extract. Initially, physiochemical and psychometric studies were performed to visualize the compliance of moisturizers with the skin. The clinical study was carried out in six groups of six healthy human volunteers (aged 20-25 years) each applying moisturizers twice daily over a period of 3 weeks in their forearm. The skin properties measured were conductance, glow and appearance. The results indicated that all the moisturizers show moisturizing effect in a time-dependent pattern and the maximum increase in skin conductance was 168.125 and 165.24% for A2 and A1, respectively. Ranking of moisturizers based on conductance as well as physicochemical analysis is A2 > A1 > A4 > A3 > A5 > A6. It was found that the formulation A2 having wheat germ oil, Aloe vera extract and turmeric extract in combination showed best results due to their synergistic effect and wheat germ oil or Aloe extract, when present separately produced skin hydration to lesser extent.
使用多种草本保湿剂改善皮肤水合特性是化妆品制剂的最新进展,以避免化学保湿剂的有害影响。该研究的主要目的是根据成分的水合作用效率,确定不同市售草本保湿剂的选择偏好。制剂选择的标准是含有草本成分、小麦胚芽油和芦荟提取物。最初,进行了物理化学和心理测量研究,以观察保湿剂与皮肤的相容性。临床研究在六组健康的人类志愿者(年龄20 - 25岁)中进行,每组六人,每人每天在前臂涂抹保湿剂两次,持续3周。测量的皮肤特性包括电导率、光泽度和外观。结果表明,所有保湿剂均呈现出随时间变化的保湿效果,A2和A1的皮肤电导率最大增幅分别为168.125%和165.24%。基于电导率以及物理化学分析对保湿剂的排名为A2 > A1 > A4 > A3 > A5 > A6。研究发现,含有小麦胚芽油、芦荟提取物和姜黄提取物组合的制剂A2由于其协同作用显示出最佳效果,而单独存在的小麦胚芽油或芦荟提取物产生的皮肤水合作用程度较小。