Roy Anupam, Srivastava Suneel Kumar, Shrivastava Shanker Lal, Mandal Amit Kumar
Laboratory of Food Chemistry and Technology, Department of Chemical Engineering, Birla Institute of Technology Mesra, Ranchi 835215, Jharkhand, India.
Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
ACS Omega. 2020 Dec 9;5(50):32617-32631. doi: 10.1021/acsomega.0c04957. eCollection 2020 Dec 22.
Microbial infections originating from medical care facilities are raising serious concerns across the globe. Therefore, nanotechnology-derived nanostructures have been investigated and explored due to their promising characteristics. In view of this, silver-based antimicrobial hydrogels as an alternative to antibiotic-based creams could play a crucial role in combating such infections. Toward this goal, we report a simple method for the synthesis and assembly of silver nanoparticles in a biopolymer physical gel derived from plant in imparting antimicrobial properties against nosocomial pathogens. Synthesized silver nanoparticles (diameter, 30 ± 10 nm) were uniformly distributed inside the hydrogel. Such synthesized hydrogel assembly of silver nanoparticles dispersed in the biopolymer matrix exhibited hemocompatibility and antimicrobial and antibiofilm characteristics against nosocomial pathogens. The developed hydrogel as a surface coating offers reduced hardness and modulus value, thereby minimizing the brittleness tendency of the gel in the dried state. Hence, we believe that the hierarchical assembly of our hydrogel owing to its functional activity, host toxicity, and stability could possibly be used as an antimicrobial ointment for bacterial infection control.
源自医疗机构的微生物感染正引起全球的严重关注。因此，由于其具有良好的特性，基于纳米技术的纳米结构已得到研究和探索。有鉴于此，银基抗菌水凝胶作为抗生素乳膏的替代品，在对抗此类感染方面可能发挥关键作用。为实现这一目标，我们报告了一种在源自植物的生物聚合物物理凝胶中合成和组装银纳米颗粒的简单方法，该凝胶具有针对医院病原体的抗菌特性。合成的银纳米颗粒（直径为30±10纳米）均匀分布在水凝胶内部。这种分散在生物聚合物基质中的银纳米颗粒合成水凝胶组件表现出血液相容性以及针对医院病原体的抗菌和抗生物膜特性。所开发的作为表面涂层的水凝胶具有降低的硬度和模量值，从而使凝胶在干燥状态下的脆性倾向最小化。因此，我们认为，由于其功能活性、宿主毒性和稳定性，我们的水凝胶的分级组装可能用作控制细菌感染的抗菌软膏。
