Knauth Peter, Acevedo-Hernández Gustavo J, Cano M Eduardo, Gutiérrez-Lomelí Melesio, López Zaira
Cell Biology Laboratory, Centro Universitario de la Ciénega, Universidad de Guadalajara, Av. Universidad 1115, 47810 Ocotlán, JAL, Mexico.
Laboratorio de Biología Molecular Vegetal, Centro Universitario de la Ciénega, Universidad de Guadalajara, Av. Universidad 1115, 47810 Ocotlán, JAL, Mexico.
Evid Based Complement Alternat Med. 2018 Feb 28;2018:3610364. doi: 10.1155/2018/3610364. eCollection 2018.
Seven out of eight methanolic extracts from five plants native to Mexico were inactive against ten bacterial strains of clinical interest. The fruit extract of inhibited the bacteria (MIC = 4375 g/ml), (MIC = 1094 g/ml), and (MIC = 137 g/ml). The fruit extract of was with CC = 45 g/ml most cytotoxic against the cell-line Caco-2, followed by the leaf extract from (CC = 126 g/ml); interestingly, leaves of (CC = 563 g/ml) and bark of (CC = 347 g/ml) extracts were much less cytotoxic. We describe for the first time the cytotoxic effect from extracts of the aerial parts and the flowers of (CC = 323 g/ml and CC = 250 g/ml, resp.). Phytochemical analysis demonstrated for both extracts high tannin and saponin and low flavonoid content, while terpenoids were found in the flowers. For the first time we report a cytotoxicological study on an extract of (CC = 356 g/ml) and likewise the bark extract from (CC = 342 g/ml). In conclusion the fruit extract of is a potential candidate for further biological studies.
从墨西哥本土五种植物中提取的八种甲醇提取物中的七种，对十种具有临床研究意义的细菌菌株没有活性。[植物名称1]的果实提取物对[细菌名称1]（最低抑菌浓度=4375μg/ml）、[细菌名称2]（最低抑菌浓度=1094μg/ml）和[细菌名称3]（最低抑菌浓度=137μg/ml）有抑制作用。[植物名称2]的果实提取物对Caco-2细胞系的细胞毒性最大，半数致死浓度（CC）=45μg/ml，其次是[植物名称2]的叶提取物（CC=126μg/ml）；有趣的是，[植物名称3]的叶提取物（CC=563μg/ml）和[植物名称4]的树皮提取物（CC=347μg/ml）的细胞毒性要小得多。我们首次描述了[植物名称5]地上部分和花的提取物的细胞毒性作用（分别为CC=323μg/ml和CC=250μg/ml）。植物化学分析表明，两种提取物的单宁和皂苷含量高，黄酮含量低，而在花中发现了萜类化合物。我们首次报道了对[植物名称6]提取物（CC=356μg/ml）以及同样对[植物名称7]树皮提取物（CC=342μg/ml）的细胞毒性研究。总之，[植物名称2]的果实提取物是进一步进行生物学研究的潜在候选物。
