Division of Rheumatology, University of California, San Francisco, USA,
Curr Rev Musculoskelet Med. 2011 Sep;4(3):99-104. doi: 10.1007/s12178-011-9088-5.
This article reviews the published risk factors associated with incident osteoarthritis of the lower extremity weight-bearing joints. Systemic risk factors include factors such as age, ethnicity, gender and genetic variables. Local risk factors are variables such as obesity, previous knee injury and occupational activities. Challenges in the study of incident osteoarthritis, and promising potential future study directions are also reviewed.
本文回顾了已发表的与下肢负重关节骨关节炎发病相关的危险因素。全身性危险因素包括年龄、种族、性别和遗传等因素。局部危险因素则有肥胖、膝关节既往损伤和职业活动等变量。文中还讨论了发病性骨关节炎研究中面临的挑战,以及未来有前景的研究方向。