Athlin L, Blind P J, Angström T
Department of Surgery, University Hospital, Umeå, Sweden.
Acta Chir Scand. 1990 Jan;156(1):91-4.
The results of fine-needle aspiration biopsy of pancreatic masses in 79 patients (percutaneous with ultrasonic guidance in 23 and peroperative in 56) were evaluated and correlated to survival (follow-up at least 2 years). The original biopsy diagnosis was malignancy in 41 patients, histologically confirmed in 19, all but two of whom died of cancer within 18 months. None of the 22 patients without histologic verification of the primary malignant cytodiagnosis survived for 18 months. The fine-needle biopsy showed benign cells in 30 patients, in 13 of whom histologic diagnosis was obtained, revealing carcinoma in seven. Six of these seven died within a year, but of the six with histologically benign lesion, five survived for more than 2 years. All 17 patients without histologic verification of benign aspiration biopsy findings survived more than 24 months. The biopsy diagnosis was inconclusive in eight patients. Four of them proved to have carcinoma and died within 18 months. The sensitivity of fine-needle aspiration biopsy of the pancreas was 76% in this study and the predictive value for malignancy was 100%.
对79例胰腺肿块患者的细针穿刺活检结果（23例经皮超声引导下穿刺，56例术中穿刺）进行了评估，并与生存情况（随访至少2年）相关联。最初的活检诊断为恶性的患者有41例，其中19例经组织学证实，除2例之外，其余患者均在18个月内死于癌症。22例未经过组织学证实原发性恶性细胞诊断的患者中，无一例存活超过18个月。细针活检显示30例患者为良性细胞，其中13例获得了组织学诊断，7例显示为癌。这7例中的6例在一年内死亡，但6例组织学为良性病变的患者中，5例存活超过2年。17例未经过组织学证实细针穿刺活检良性结果的患者均存活超过24个月。8例患者的活检诊断不明确。其中4例证实为癌，并在18个月内死亡。本研究中胰腺细针穿刺活检的敏感性为76%，对恶性肿瘤的预测价值为100%。
