Pérez-Losada Flor de Liz, Estrugo-Devesa Albert, Castellanos-Cosano Lissett, Segura-Egea Juan José, López-López José, Velasco-Ortega Eugenio
Department of Odontostomatology, Faculty of Medicine and Health Sciences (School of Dentistry), University of Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Oral Health and Masticatory System Group (Bellvitge Biomedical Research Institute) IDIBELL, University of Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
J Clin Med. 2020 Feb 17;9(2):540. doi: 10.3390/jcm9020540.
Investigate if there is an association between apical periodontitis and diabetes mellitus.
A bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical analysis. The variables analyzed were the prevalence of Apical Periodontitis (AP) among teeth and patients with Diabetes Mellitus (DM).
Of the total studies found, only 21 met the inclusion criteria. Ten clinical studies on animals, ten studies on humans and a systematic review were included. Meta-analysis shows that the prevalence of teeth with apical periodontitis among patients with diabetes mellitus has an odds ratio of 1.166 corresponding to 507 teeth with AP + DM and 534 teeth with AP without DM. The prevalence of patients with AP and DM shows an odds ratio of 1.552 where 91 patients had AP + DM and 582 patients AP without DM.
Scientific evidence suggests that there could be a common physiopathological factor between apical periodontitis and diabetes mellitus but more prospective studies are needed to investigate the association between these two diseases.
研究根尖周炎与糖尿病之间是否存在关联。
使用关键词“根尖周炎”和“糖尿病”在Medline/PubMed、Scopus和Cochrane数据库中进行文献检索。纳入以英文撰写的、在动物或人类身上进行的已发表论文。使用OpenMeta（分析）工具进行荟萃分析以进行统计分析。分析的变量是糖尿病患者牙齿和患者中根尖周炎（AP）的患病率。
在检索到的所有研究中，只有21项符合纳入标准。包括10项动物临床研究、10项人类研究和1项系统评价。荟萃分析表明，糖尿病患者中患有根尖周炎的牙齿患病率的优势比为1.166，对应507颗患有根尖周炎合并糖尿病的牙齿和534颗患有根尖周炎但无糖尿病的牙齿。患有根尖周炎合并糖尿病的患者患病率的优势比为1.552，其中91例患者患有根尖周炎合并糖尿病，582例患者患有根尖周炎但无糖尿病。
科学证据表明根尖周炎和糖尿病之间可能存在共同的生理病理因素，但需要更多前瞻性研究来调查这两种疾病之间的关联。
