中等强度静磁场增强兔软骨损伤修复。

A moderate-intensity static magnetic field enhances repair of cartilage damage in rabbits.

机构信息

Bone & Joint Diseases Research Center, Shiraz University of Medical Sciences, Iran.

出版信息

Arch Med Res. 2011 May;42(4):268-73. doi: 10.1016/j.arcmed.2011.06.004.

DOI:10.1016/j.arcmed.2011.06.004

PMID:21820604

Abstract

BACKGROUND AND AIMS

Electromagnetic fields have been proposed to enhance healing of cartilage defects by stimulation of chondrocyte proliferation, proteoglycan synthesis as well as decreasing pain and improving motion in osteoarthritic patients. However, the effects of a moderate-intensity static magnetic field on cartilage repair have not been investigated. This study tries to determine the effects of a moderate-intensity permanent magnetic field of 40 mT on cartilage repair.

METHODS

Defects of 3 mm in diameter and 6 mm in depth were made on the weight bearing surface of the right medial femoral condyle of 30 rabbits. The animals were divided randomly into three equal groups (magnet, sham and control). In the magnet group, cylindrical permanent magnets were implanted subcutaneously medial to the medial femoral condyle, while in the sham group the cylindrical ceramic were not magnetized, and nothing was implanted in controls. After 12 weeks of observation, Mankin's microscopic scoring was done on all specimens, and irregularity of surface characteristics, cell colonization, hypocellularity, cartilage matrix formation, and presence of empty lacunae were investigated.

RESULTS

Each of these characteristics showed significant differences in magnet group relative to control and sham groups (p <0.05). Mankin's score was 1.6 ± 0.6 in magnet group, 7.2 ± 1.6 in sham group and 7.7 ± 1 in control group (p <0.001).

CONCLUSIONS

[corrected] In this animal study, microscopic Mankin's scoring depicted histological improvement in cartilage of magnet group.

摘要

背景与目的

电磁场被认为可以通过刺激软骨细胞增殖、蛋白多糖合成，以及减轻疼痛和改善骨关节炎患者的运动能力，来促进软骨缺陷的愈合。然而，中等强度静磁场对软骨修复的影响尚未得到研究。本研究旨在确定 40 mT 中等强度永磁体对软骨修复的影响。

方法

在 30 只兔子的右股骨内侧髁负重面制作直径 3mm、深度 6mm 的缺损。动物随机分为三组（磁体组、假磁体组和对照组）。在磁体组中，将圆柱形永磁体植入股骨内侧髁内侧的皮下，而在假磁体组中，圆柱形陶瓷体未被磁化，对照组中则什么也不植入。观察 12 周后，对所有标本进行 Mankin 微观评分，评估表面特征不规则、细胞定植、细胞减少、软骨基质形成和空陷窝的存在。