Department of Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Curr Opin Cardiol. 2011 Nov;26(6):480-7. doi: 10.1097/HCO.0b013e32834a7035.
The management of concurrent severe carotid and coronary disease is a subject of ongoing debate in the absence of randomized clinical trials. Amidst the growing controversy, the clinician has to carefully tailor the best strategy for a given patient based on neurologic and cardiac symptoms. This review aims to compile current evidence in this area to help plan strategies for the optimal management of coexisting severe carotid and coronary disease.
Carotid revascularization with carotid endarterectomy (CEA) or stenting (CAS) is frequently performed in conjunction with coronary artery bypass surgery (CABG) in the United States for asymptomatic carotid disease. The risk of perioperative stroke with unilateral asymptomatic 70-99% carotid stenosis is likely small based on several observational data. Moreover, the risk associated with both staged and combined CEA-CABG procedures in the asymptomatic population may outweigh any benefit. Carotid artery stenting is an alternative option in patients with severe coronary disease who are considered 'high risk' for CEA. Neurologically symptomatic patients require carotid revascularization prior to or in conjunction with CABG surgery. Ultimately, the choice of carotid revascularization or conservative management will depend on clinical characteristics, anatomy, and local expertise.
Severe carotid disease in the CABG population is often unilateral and asymptomatic. Based on the available data, conservative carotid therapy in the low-risk asymptomatic individuals is likely the best treatment option. Carotid revascularization may be justified in symptomatic or high-risk patients such as those with contralateral carotid occlusion or bilateral severe stenosis.
由于缺乏随机临床试验,同时存在严重颈动脉和冠状动脉疾病的患者的治疗方案选择一直存在争议。在争议不断的情况下,临床医生必须根据患者的神经和心脏症状,精心为患者制定最佳策略。本文旨在汇总该领域的现有证据,以帮助制定最佳治疗方案,以同时治疗严重的颈动脉和冠状动脉疾病。
在美国,无症状颈动脉疾病患者通常会同时进行颈动脉内膜切除术(CEA)或支架置入术(CAS)来进行颈动脉血运重建,以及冠状动脉旁路移植术(CABG)。根据几项观察性数据,单侧无症状颈动脉狭窄 70-99%患者发生围手术期卒中的风险可能很小。此外,在无症状人群中,分期和联合 CEA-CABG 手术的风险可能超过任何获益。对于有严重冠状动脉疾病且被认为 CEA 风险较高的患者,颈动脉支架置入术是一种替代选择。有神经系统症状的患者需要在 CABG 手术之前或同时进行颈动脉血运重建。最终,颈动脉血运重建或保守治疗的选择将取决于临床特征、解剖结构和当地专业知识。
CABG 患者的严重颈动脉疾病通常为单侧和无症状。基于现有数据,低风险无症状患者的保守颈动脉治疗可能是最佳治疗选择。对于有症状或高风险的患者,如对侧颈动脉闭塞或双侧严重狭窄的患者,颈动脉血运重建可能是合理的。