Shapiro R A, Siskind V, Schofield F D, Stallman N, Worswick D A, Marmion B P
Department of Social and Preventive Medicine, University of Queensland, Adelaide, South Australia.
Epidemiol Infect. 1990 Apr;104(2):267-73. doi: 10.1017/s0950268800059446.
A limited, randomized, blind, placebo-controlled trial of Q fever and influenza vaccines has been conducted in three Queensland abattoirs on a sequential analysis design. Ninety-eight subjects were given Q fever vaccine and 102 influenza vaccine. Q fever cases were observed in unvaccinated workers in all three abattoirs during the period of observation. A total of seven Q fever cases in one group, one more than the number required to achieve statistical significance between the two vaccine groups, was reached after 15 months with the cases coming from two of the abattoirs. These Q fever cases were in the group which had been given influenza vaccine and none in that given Q fever vaccine. Symptomless seroconversion rates of 24% were found in the remaining influenza virus vaccinees, and those without immunity were given Q fever vaccine.
在昆士兰的三个屠宰场，采用序贯分析设计，开展了一项关于Q热疫苗和流感疫苗的小型随机双盲安慰剂对照试验。98名受试者接种了Q热疫苗，102名受试者接种了流感疫苗。在观察期内，所有三个屠宰场的未接种疫苗的工人中均出现了Q热病例。15个月后，一组共出现7例Q热病例，比两个疫苗组之间达到统计学显著性所需的病例数多1例，这些病例来自两个屠宰场。这些Q热病例出现在接种流感疫苗的组中，接种Q热疫苗的组中无一例。在其余接种流感病毒疫苗的人中，无症状血清转化率为24%，对那些没有免疫力的人接种了Q热疫苗。
