捷克斯洛伐克职业性接触Q热人群中一种Q热化学疫苗的免疫原性和反应原性
Immunogenicity and reactogenicity of a Q fever chemovaccine in persons professionally exposed to Q fever in Czechoslovakia.
作者信息
Kazár J, Brezina R, Palanová A, Tvrdá B, Schramek S
出版信息
Bull World Health Organ. 1982;60(3):389-94.
Abstract
An immunization trial carried out on 1310 persons professionally exposed to Q fever confirmed the suitability of a chemovaccine for field use. Its immunogenicity and reactogenicity differed in three groups of subjects who differed in their previous experience of Q fever and who were given different lots of the vaccine. There was some correlation between reactogenicity of the vaccine and pre-immunization positivity in the microagglutination and skin tests as indicators of a previous exposure. The skin test was more reliable for predicting post-immunization reactions.
摘要
一项针对1310名职业性接触Q热的人员开展的免疫试验证实了一种化学疫苗适用于现场使用。在三组既往Q热经历不同且接种不同批次疫苗的受试者中，该疫苗的免疫原性和反应原性有所不同。疫苗的反应原性与作为既往接触指标的微量凝集试验和皮肤试验中的免疫前阳性结果之间存在一定相关性。皮肤试验在预测免疫后反应方面更可靠。
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