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Cloning and expression of the putative gene coding for GTP cyclohydrolase I from Escherichia coli.

作者信息

Katzenmeier G, Schmid C, Bacher A

机构信息

Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Garching, F.R.G.

出版信息

FEMS Microbiol Lett. 1990 Jan 1;54(1-3):231-4. doi: 10.1016/0378-1097(90)90288-2.

DOI:10.1016/0378-1097(90)90288-2
PMID:2182376
Abstract

The putative gene coding for GTP cyclohydrolase I of Escherichia coli was isolated from a lambda gt11 expression vector library by using antibodies as a probe and has been subcloned on a 3.8 kb Bam HI fragment in the plasmid vector pUC13. E. coli cells carrying the recombinant plasmid designated pCYH express 100-fold increased levels of the enzyme. The protein formed under the control of the plasmid appears electrophoretically and immunochemically identical with the wild type enzyme.

摘要

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