NetDS：一个 Cytoscape 插件，用于分析生物网络动态和前馈/反馈回路结构的鲁棒性。
NetDS: a Cytoscape plugin to analyze the robustness of dynamics and feedforward/feedback loop structures of biological networks.
机构信息
School of Electrical Engineering, University of Ulsan, 93, Daehak-ro, Nam-gu, Ulsan 680-749.
出版信息
Bioinformatics. 2011 Oct 1;27(19):2767-8. doi: 10.1093/bioinformatics/btr466. Epub 2011 Aug 9.
SUMMARY
NetDS is a novel Cytoscape plugin that conveniently simulates dynamics related to robustness, and examines structural properties with respect to feedforward/feedback loops. It can evaluate how robustly a network sustains a stable state against mutations by employing a Boolean network model. In addition, the plugin can examine all feedforward/feedback loops appearing in a network and determine whether or not a pair of loops is coupled. Random networks can also be generated to evaluate whether or not an interesting finding in real biological networks is significantly random.
AVAILABILITY
NetDS is freely available for non-commercial purposes at http://netds.sourceforge.net/.
CONTACT
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
摘要
NetDS 是一个新颖的 Cytoscape 插件，它可以方便地模拟与稳健性相关的动力学，并检查与前馈/反馈回路有关的结构特性。它可以通过使用布尔网络模型来评估网络在面对突变时保持稳定状态的稳健程度。此外，该插件还可以检查网络中出现的所有前馈/反馈回路，并确定回路对是否耦合。还可以生成随机网络，以评估真实生物网络中的有趣发现是否具有显著的随机性。
可用性
NetDS 可免费用于非商业目的，网址为 http://netds.sourceforge.net/。
联系方式
补充信息
补充数据可在 Bioinformatics 在线获取。
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