神经系统模式形成的演化：来自海胆发育的启示。
The evolution of nervous system patterning: insights from sea urchin development.
机构信息
National Institute for Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Development. 2011 Sep;138(17):3613-23. doi: 10.1242/dev.058172.
Abstract
Recent studies of the sea urchin embryo have elucidated the mechanisms that localize and pattern its nervous system. These studies have revealed the presence of two overlapping regions of neurogenic potential at the beginning of embryogenesis, each of which becomes progressively restricted by separate, yet linked, signals, including Wnt and subsequently Nodal and BMP. These signals act to specify and localize the embryonic neural fields - the anterior neuroectoderm and the more posterior ciliary band neuroectoderm - during development. Here, we review these conserved nervous system patterning signals and consider how the relationships between them might have changed during deuterostome evolution.
摘要
最近对海胆胚胎的研究阐明了定位和模式其神经系统的机制。这些研究揭示了在胚胎发生的早期存在两个重叠的神经发生潜能区域，每个区域都被单独的、但相互关联的信号逐渐限制，包括 Wnt 以及随后的 Nodal 和 BMP。这些信号在发育过程中作用于指定和定位胚胎神经区域——前神经外胚层和更后的纤毛带神经外胚层。在这里，我们回顾这些保守的神经系统模式信号，并考虑它们之间的关系在后口动物进化过程中可能发生了怎样的变化。
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