Department of Neurology, MS Centre ErasMS, Erasmus University Medical Centre, The Netherlands.
Mult Scler. 2011 Dec;17(12):1527-30. doi: 10.1177/1352458511412995. Epub 2011 Aug 9.
The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 assay in 273 patients with inflammatory CNS demyelination. The assay had a specificity of 99% and a sensitivity of 56% to detect all NMO patients and of 74% to detect the recurrent NMO patients, similar to the initial studies reported. AQP4 antibodies were absent in monophasic NMO patients, while samples in recurrent cases remained positive during follow-up. We conclude that the pathogenesis of monophasic NMO may be different from that of relapsing NMO.
水通道蛋白-4（AQP4）抗体的检测提高了视神经脊髓炎（NMO）的诊断水平。我们评估了最近建立的基于细胞的抗 AQP4 检测方法在 273 例中枢神经系统炎症性脱髓鞘患者中的应用。该检测方法对所有 NMO 患者的特异性为 99%，敏感性为 56%，对复发性 NMO 患者的敏感性为 74%，与最初的研究结果相似。单相 NMO 患者的 AQP4 抗体为阴性，而在随访过程中复发病例的样本仍为阳性。我们得出结论，单相 NMO 的发病机制可能与复发性 NMO 不同。
