用于牙科和颅面应用的纳米纤维支架。
Nanofibrous scaffolds for dental and craniofacial applications.
机构信息
Department of Biomedical Engineering, 1011 North University Ave., Room 2211, USA.
出版信息
J Dent Res. 2012 Mar;91(3):227-34. doi: 10.1177/0022034511417441. Epub 2011 Aug 9.
Abstract
Tissue-engineering solutions often harness biomimetic materials to support cells for functional tissue regeneration. Three-dimensional scaffolds can create a multi-scale environment capable of facilitating cell adhesion, proliferation, and differentiation. One such multi-scale scaffold incorporates nanofibrous features to mimic the extracellular matrix along with a porous network for the regeneration of a variety of tissues. This review will discuss nanofibrous scaffold synthesis/fabrication, biological effects of nanofibers, their tissue- engineering applications in bone, cartilage, enamel, dentin, and periodontium, patient-specific scaffolds, and incorporated growth factor delivery systems. Nanofibrous scaffolds cannot only further the field of craniofacial regeneration but also advance technology for tissue-engineered replacements in many physiological systems.
摘要
组织工程解决方案通常利用仿生材料来支持细胞的功能组织再生。三维支架可以创建一个多尺度的环境，能够促进细胞的黏附、增殖和分化。这样的多尺度支架包含纳米纤维特征，以模拟细胞外基质，并具有多孔网络，以促进各种组织的再生。这篇综述将讨论纳米纤维支架的合成/制造、纳米纤维的生物学效应、它们在骨、软骨、牙釉质、牙本质和牙周组织的组织工程应用、患者特异性支架和包含的生长因子输送系统。纳米纤维支架不仅可以进一步推动颅面再生领域的发展，还可以推动许多生理系统中组织工程替代物的技术发展。
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