Public Institution Odontologijos studija, Lithuania.
Medicina (Kaunas). 2011;47(4):193-9.
Periodontal diseases are among the most common chronic infections in humans. Chronic low-level bacteremia and a septicemic inflammatory response have been suggested as a pathogenetic link between periodontal disease and atherosclerosis, diabetes and other systemic diseases. All this significantly increases the relevance of the search for the means for treatment and prevention of periodontal diseases. The aim of the present study was to evaluate blood count and the antioxidant capacity of venous blood, blood plasma, and serum in patients with periodontitis and control subjects with healthy periodontal tissues, and to investigate the effect of the homeopathic medication Traumeel S on the antioxidant capacity of venous blood, plasma, and serum.
The study was performed using venous blood of 21 individuals with chronic periodontitis and 22 healthy subjects. Reduction properties of venous blood, blood plasma, and serum were investigated using the method of reduction of nitroblue tetrazolium, proposed by Demehin et al.
The data showed that there was no significant difference in venous blood hemoglobin levels or erythrocyte counts between the groups, while significantly higher leukocyte counts were observed in the periodontitis group (P<0.05). The antioxidant capacity of blood plasma was significantly higher in the periodontitis group than it was in the controls (P<0.05). Meanwhile, the antioxidant capacity of serum was significantly lower in the periodontitis group as compared with controls (P<0.05). The preparation Traumeel S had no effect on the antioxidant capacity of venous blood or blood plasma in the studied groups.
Compared to healthy individuals, the antioxidant capacity of blood plasma in patients with periodontitis was higher, while the antioxidant capacity of serum was lower. The homeopathic medication Traumeel S had no effect on the antioxidant capacity of venous blood, blood plasma, or serum. Our findings concerning the elevated leukocyte counts in venous blood of patients with periodontitis confirm the presumption that periodontal diseases cause low-grade systemic inflammation induced by the host response to periodontal bacteria.
牙周病是人类最常见的慢性感染之一。慢性低水平菌血症和全身炎症反应被认为是牙周病与动脉粥样硬化、糖尿病和其他全身性疾病之间的病理联系。所有这些都显著增加了寻找牙周病治疗和预防方法的重要性。本研究旨在评估牙周炎患者和健康牙周组织对照者的静脉血、血浆和血清的血细胞计数和抗氧化能力，并研究顺势疗法药物 Traumeel S 对静脉血、血浆和血清抗氧化能力的影响。
本研究使用了 21 名慢性牙周炎患者和 22 名健康受试者的静脉血。使用 Demehin 等人提出的硝基四唑氮还原法研究了静脉血、血浆和血清的还原特性。
数据显示，两组间静脉血血红蛋白水平或红细胞计数无显著差异，而牙周炎组白细胞计数显著升高（P<0.05）。与对照组相比，牙周炎组的血浆抗氧化能力显著升高（P<0.05）。同时，与对照组相比，牙周炎组血清的抗氧化能力显著降低（P<0.05）。研究中，制剂 Traumeel S 对研究组静脉血或血浆的抗氧化能力没有影响。
与健康个体相比，牙周炎患者的血浆抗氧化能力较高，而血清抗氧化能力较低。顺势疗法药物 Traumeel S 对静脉血、血浆或血清的抗氧化能力没有影响。我们发现牙周炎患者静脉血白细胞计数升高，证实了牙周病引起宿主对牙周细菌反应引起的低度全身炎症的假设。
