Iqbal P Safar, Khan S Nubesh, Haris Mohamed, Narayanan Mahesh, Laju S, Kumar Swaminathan Senthil
Assistant Professor, Department of Periodontics, Malabar Dental College, Kerala, India.
Assistant Professor, Department of Periodontics, Sri Sankara Dental College, Kerala, India.
J Int Oral Health. 2015;7(Suppl 2):48-51.
"Aggressive periodontitis (AgP) is a destructive disease characterized by the following: The involvement of multiple teeth with a distinctive pattern of periodontal tissue loss; a high rate of disease progression; an early age of onset; and the absence of systemic diseases.'' Chronic low-level bacteremia and systemic inflammatory response have been suggested as a pathogenic link between periodontal disease and systemic disease. The present study was aimed to assess the levels of systemic inflammatory markers in patients with AgP.
A sample of 50 systemically healthy patients comprised two groups, based on full mouth periodontal examination: Group I healthy individuals, includes 25 periodontally healthy subjects with fully functioning dentition. Group II includes 25 patients diagnosed clinically as AgP. Laboratory blood investigation included white blood cell (WBC) count, neutrophil count, lymphocyte count, and platelet count. Serum protein parameters included total protein (TP), albumin (ALB), and globulin (GLB). Periodontal clinical parameters including plaque index, gingival index, probing pocket depth, and clinical attachment level were recorded.
Data analysis shows an increase in WBC, neutrophil, lymphocyte, and platelet count and a decrease in TP, ALB, and GLB in AgP patients when compared to healthy individuals.
Results of the present study shows an increase in blood parameters and decrease in serum protein parameters in AgP. Hence, AgP could be considered as one of the risk factors associated with the cardiovascular diseases as assessed by changes in the level of systemic inflammatory markers observed.
“侵袭性牙周炎（AgP）是一种具有以下特征的破坏性疾病：多颗牙齿受累，伴有独特的牙周组织丧失模式；疾病进展速度快；发病年龄早；且无全身性疾病。”慢性低水平菌血症和全身炎症反应被认为是牙周病与全身性疾病之间的致病联系。本研究旨在评估侵袭性牙周炎患者的全身炎症标志物水平。
根据全口牙周检查，选取50名全身健康的患者组成两组：第一组为健康个体，包括25名牙周健康且牙列功能正常的受试者。第二组包括25名临床诊断为侵袭性牙周炎的患者。实验室血液检查包括白细胞（WBC）计数、中性粒细胞计数、淋巴细胞计数和血小板计数。血清蛋白参数包括总蛋白（TP）、白蛋白（ALB）和球蛋白（GLB）。记录牙周临床参数，包括菌斑指数、牙龈指数、探诊袋深度和临床附着水平。
数据分析显示，与健康个体相比，侵袭性牙周炎患者的白细胞、中性粒细胞、淋巴细胞和血小板计数增加，总蛋白、白蛋白和球蛋白减少。
本研究结果显示，侵袭性牙周炎患者血液参数升高，血清蛋白参数降低。因此，根据观察到的全身炎症标志物水平变化评估，侵袭性牙周炎可被视为与心血管疾病相关的危险因素之一。
