Department of Ophthalmology, School of Medicine, Celal Bayar University, Manisa, Turkey.
Graefes Arch Clin Exp Ophthalmol. 2013 Feb;251(2):555-8. doi: 10.1007/s00417-012-2089-2. Epub 2012 Jun 22.
Vernal keratoconjunctivitis (VKC) is a chronic, bilateral, seasonally exacerbated, allergic inflammation of the ocular surface, involving bulbar and ⁄ or tarsal conjunctiva and cornea. The ocular response analyzer (ORA) measures corneal biomechanical properties in vivo by monitoring and analyzing the corneal behavior when its structure is submitted to a force induced by an air jet. This study was designed to examine corneal biomechanical properties and intraocular pressure in patients with VKC, and to compare with control eyes.
ORA measurements were performed on the both eyes of 26 patients with VKC (group I) and 14 healthy children who served as the control group (group II). Corneal hysteresis (CH), corneal resistance factor (CRF) and intraocular pressure [Goldmann correlated (IOPg) and corneal compensated (IOPcc)] were recorded with ORA.
Mean age of patients with VKC and control groups were 11.3 ± 5.8 and 10.6 ± 1.9 years for groups I and II respectively. Mean (± SD) of the CH and CRF readings were 10.1 ± 1.6 versus 10.5 ± 1.6 (p > 0.05) and 9.5 ± 1.7 versus 10.8 ± 1.7 mmHg (p < 0.05), in groups I and II respectively. Mean (± SD) of the IOPg and IOPcc recordings were 13.3 ± 3.4 versus 16.6 ± 3.6 mmHg (p < 0.05) and 14.3 ± 3.4 versus 16.9 ± 3.7 mmHg (p > 0.05) in groups I and II respectively. Statistical analysis revealed significant differences for CRF and IOPg between the study groups.
The mean CRF and IOPg values of patients with VKC were lower than those of controls. According to the results of our study, one can conclude that corneal biomechanical property, CRF, could be different in VKC patients compared to normals.
春季角结膜炎(VKC)是一种慢性、双侧、季节性加重的眼表过敏炎症,涉及球结膜和/或睑结膜和角膜。眼反应分析仪(ORA)通过监测和分析角膜在空气喷射力作用下的结构变化,测量活体角膜生物力学特性。本研究旨在检查 VKC 患者的角膜生物力学特性和眼压,并与对照组进行比较。
对 26 例 VKC 患者(I 组)和 14 例健康儿童(对照组)的双眼进行 ORA 测量。用 ORA 记录角膜滞后(CH)、角膜阻力因子(CRF)和眼压[Goldmann 相关眼压(IOPg)和角膜补偿眼压(IOPcc)]。
VKC 组和对照组患者的平均年龄分别为 11.3 ± 5.8 岁和 10.6 ± 1.9 岁。I 组和 II 组的 CH 和 CRF 读数平均值(±SD)分别为 10.1 ± 1.6 与 10.5 ± 1.6(p>0.05)和 9.5 ± 1.7 与 10.8 ± 1.7mmHg(p<0.05)。I 组和 II 组的 IOPg 和 IOPcc 记录平均值(±SD)分别为 13.3 ± 3.4 与 16.6 ± 3.6mmHg(p<0.05)和 14.3 ± 3.4 与 16.9 ± 3.7mmHg(p>0.05)。统计分析显示两组间 CRF 和 IOPg 差异有统计学意义。
VKC 患者的平均 CRF 和 IOPg 值低于对照组。根据我们的研究结果,可以得出结论,与正常相比,VKC 患者的角膜生物力学特性 CRF 可能不同。