阿什肯纳兹犹太人群体中前列腺癌的遗传结构。
Genetic architecture of prostate cancer in the Ashkenazi Jewish population.
机构信息
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Br J Cancer. 2011 Sep 6;105(6):864-9. doi: 10.1038/bjc.2011.307. Epub 2011 Aug 9.
BACKGROUND
Recently, numerous prostate cancer risk loci have been identified, some of which show association in specific populations. No study has yet investigated whether these single nucleotide polymorphisms (SNPs) are associated with prostate cancer in the Ashkenazi Jewish (AJ) population.
METHODS
A total of 29 known prostate cancer risk SNPs were genotyped in 963 prostate cancer cases and 613 controls of AJ ancestry. These data were combined with data from 1241 additional Ashkenazi controls and tested for association with prostate cancer. Correction for multiple testing was performed using the false discovery rate procedure.
RESULTS
Ten of twenty-three SNPs that passed quality control procedures were associated with prostate cancer risk at a false discovery rate of 5%. Of these, nine were originally discovered in studies of individuals of European ancestry. Based on power calculations, the number of significant associations observed is not surprising.
CONCLUSION
We see no convincing evidence that the genetic architecture of prostate cancer in the AJ population is substantively different from that observed in other populations of European ancestry.
背景
最近，许多前列腺癌风险基因座已被确定，其中一些在特定人群中表现出相关性。目前还没有研究调查这些单核苷酸多态性（SNP）是否与阿什肯纳兹犹太人（AJ）人群中的前列腺癌有关。
方法
对 963 例前列腺癌病例和 613 例 AJ 血统对照者的 29 个已知前列腺癌风险 SNP 进行了基因分型。这些数据与另外 1241 名阿什肯纳兹对照者的数据相结合，并进行了与前列腺癌的相关性检测。使用错误发现率程序对多重检测进行了校正。
结果
经过质量控制程序的 23 个 SNP 中有 10 个与前列腺癌风险相关，其假发现率为 5%。其中，有 9 个是在对欧洲血统个体的研究中首次发现的。根据功效计算，观察到的显著关联数量并不令人意外。
结论
我们没有发现令人信服的证据表明 AJ 人群中前列腺癌的遗传结构与其他欧洲血统人群中的遗传结构有实质性的不同。
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