Isberg R R
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Mol Biol Med. 1990 Feb;7(1):73-82.
For many bacterial species, entry into mammalian cells is an important step toward establishing an infectious disease. Genetic and molecular techniques have revealed many important features of the entry process. As an example of this approach, the enteric pathogen Yersinia pseudotuberculosis has been used as a model system for bacterial penetration. This analysis has uncovered at least three different pathways for entry of the microorganism into cultured mammalian cells. These pathways differ in regards to their tissue specificities as well as the regulatory signals that control their expression. One of these pathways, promoted by the Y. pseudotuberculosis outer membrane protein invasin, has been studied in detail. This single factor is sufficient to promote entry of inert particles by binding multiple integrin receptors during cellular uptake. The significance of multiple pathways for entry as well as the binding of multiple receptors is discussed.
对于许多细菌物种而言，进入哺乳动物细胞是引发传染病的重要一步。遗传和分子技术揭示了进入过程的许多重要特征。作为这种方法的一个例子，肠道病原体假结核耶尔森菌已被用作细菌穿透的模型系统。该分析揭示了微生物进入培养的哺乳动物细胞的至少三种不同途径。这些途径在组织特异性以及控制其表达的调节信号方面存在差异。其中一条途径由假结核耶尔森菌外膜蛋白侵袭素促进，已得到详细研究。在细胞摄取过程中，这一单一因子通过结合多种整合素受体足以促进惰性颗粒的进入。本文讨论了多种进入途径以及多种受体结合的意义。
