牙龈卟啉单胞菌FDC381在体外可在人类口腔上皮细胞内繁殖并持续存在。
Porphyromonas gingivalis FDC381 multiplies and persists within human oral epithelial cells in vitro.
作者信息
Madianos P N, Papapanou P N, Nannmark U, Dahlén G, Sandros J
机构信息
Department of Oral Microbiology, Faculty of Odontology, Göteborg University, Sweden.
出版信息
Infect Immun. 1996 Feb;64(2):660-4. doi: 10.1128/iai.64.2.660-664.1996.
Abstract
Porphyromonas gingivalis FDC381 replication and persistence within KB epithelial cells in vitro were studied by means of an antibiotic protection assay and electron microscopy. Intracellular counts decreased during the first 24 h; showed a threefold increase during the second day, indicating intracellular multiplication; and after 8 days declined to levels approximating 40% of the initial invasion. The ability of P. gingivalis to persist and multiply within epithelial cells may constitute a pathogenic mechanism in periodontal disease.
摘要
通过抗生素保护试验和电子显微镜研究了牙龈卟啉单胞菌FDC381在体外KB上皮细胞内的复制和存活情况。在最初的24小时内细胞内计数下降；在第二天增加了三倍，表明细胞内有增殖；8天后下降到接近初始侵袭量40%的水平。牙龈卟啉单胞菌在上皮细胞内持续存在和增殖的能力可能是牙周疾病的一种致病机制。
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