Department of Orthopaedics, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
Trends Biotechnol. 2011 Dec;29(12):601-6. doi: 10.1016/j.tibtech.2011.07.001. Epub 2011 Aug 9.
In engineered bone grafts, the combined actions of bone-forming cells, matrix and bioactive stimuli determine the eventual performance of the implant. The current notion is that well-built 3D constructs include the biological elements that recapitulate native bone tissue structure to achieve bone formation once implanted. The relatively new technology of organ/tissue printing now enables the accurate 3D organization of the components that are important for bone formation and also addresses issues, such as graft porosity and vascularization. Bone printing is seen as a great promise, because it combines rapid prototyping technology to produce a scaffold of the desired shape and internal structure with incorporation of multiple living cell types that can form the bone tissue once implanted.
在工程化骨移植物中，成骨细胞、基质和生物活性刺激物的联合作用决定了植入物的最终性能。目前的观点是，构建良好的 3D 结构包括能够再现天然骨组织结构的生物元素，从而实现植入后的骨形成。目前相对较新的器官/组织打印技术现在能够精确地组织对于骨形成很重要的成分，并且解决了移植物多孔性和血管化等问题。骨打印被认为是一个巨大的希望，因为它结合了快速原型制造技术，生产出所需形状和内部结构的支架，并结合了可以在植入后形成骨组织的多种活细胞类型。
