癌症药物发现面临 FACT 挑战。

Cancer drug discovery faces the FACT.

机构信息

Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02115, USA.

出版信息

Sci Transl Med. 2011 Aug 10;3(95):95ps34. doi: 10.1126/scitranslmed.3002822.

Abstract

In this issue of Science Translational Medicine, Gasparian et al. use a clever cell-based screen to identify a family of DNA-binding small molecules-curaxins-that inhibit tumor cell growth and division. The curaxins' mechanism of action pinpoints a new chromatin-remodeling factor as a therapeutic target for cancer.

摘要

本期《科学转化医学》杂志中，Gasparian 等人利用巧妙的基于细胞的筛选方法发现了一族能抑制肿瘤细胞生长和分裂的 DNA 结合小分子——卡鲁嗪。卡鲁嗪的作用机制将一种新的染色质重塑因子确定为癌症治疗靶点。