Creighton University, Omaha, Nebraska 68131, USA.
Curr Opin Clin Nutr Metab Care. 2011 Sep;14(5):440-4. doi: 10.1097/MCO.0b013e328348ed85.
To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status.
Elucidation of the cell-biologic mechanism of vitamin D action, and numerous clinical trials and observational studies relating vitamin D status to health and disease.
The distinction between deficiency and insufficiency is not useful or necessary. Serum 25(OH)D values below 120 nmol/l (48 ng/ml) are associated with preventable disease and are therefore indicative of deficiency. The upper limit of the normal range can be set at 225 nmol/l (90 ng/ml), although toxicity is rare below 500 nmol/l (200 ng/ml).
描述评估方法并总结将各种血清 25-羟维生素 D [25(OH)D]浓度与健康状况联系起来的研究。
阐明维生素 D 作用的细胞生物学机制，以及许多将维生素 D 状态与健康和疾病相关联的临床试验和观察性研究。
区分缺乏和不足是没有用处或没有必要的。血清 25(OH)D 值低于 120 nmol/l（48 ng/ml）与可预防的疾病相关，因此表明存在缺乏。正常范围的上限可以设定为 225 nmol/l（90 ng/ml），尽管在低于 500 nmol/l（200 ng/ml）时毒性很少见。
