Priyadarshini S, Ashadevi J S, Nagarjun V, Prasanna K S
Government Ayurveda Medical College, Mysore, Karnataka, India.
J Ayurveda Integr Med. 2010 Apr;1(2):114-9. doi: 10.4103/0975-9476.65085.
We report preliminary results from an ongoing series of experiments on lifespan extension by appropriately modified Ayurvedic rasayanas in animal models. Here data are presented indicating lifespan extensions of 51-55% (up to 70-95% in the pilot experiment) in a standard strain of Drosophila melanogaster (Oregon-K) using a standard rasayana (Ayurvedic herbal formulation for life-extension) suitably adapted for insects. In a first experiment, two groups of 20 unmated D. melanogaster strain Oregon-K kept at 22°C received either rasayana or standard yeast diet; days of death were recorded. Another experiment investigated possible sex differences; equal sized (N = 30) groups of similar males, females, and controls were compared. Life lengths of all controls were in the strain's usual range: in Experiment 1, control life lengths were minimum 40 to maximum 53 days; experimental group figures were 81-91 days; groups were completely separated, experimental group minimum life length being 28 days more than control group maximum life length, i.e., about 2.5 full distribution widths - a sign test for the null hypothesis yields p < 2(-20), i.e., 10(-6) as maximum p. Experiment 2 found no differences between life lengths of males and females; but the maximum life length of 30 controls (60 days in males and 66 days in females) was once again far shorter than the minimum life length of the 60 in the two experimental groups, strengthening the findings of Experiment 1. Despite group sizes being relatively small, results are conclusive: the rasayanas in question increase D. melanogaster strain Oregon-K life length. The complexity of the formulation suggests that multiple mechanisms are involved - worth further investigation.
我们报告了一系列正在进行的实验的初步结果，这些实验是关于在动物模型中通过适当改良的阿育吠陀养生法来延长寿命。这里呈现的数据表明，使用一种经过适当改良以适用于昆虫的标准养生法（用于延长寿命的阿育吠陀草药配方），标准品系的黑腹果蝇（俄勒冈-K）的寿命延长了51%-55%（在初步实验中高达70%-95%）。在第一个实验中，两组各20只未交配的黑腹果蝇品系俄勒冈-K，饲养在22°C环境下，分别给予养生法或标准酵母饮食；记录死亡天数。另一个实验研究了可能的性别差异；比较了等量大小（N = 30）的相似雄性、雌性和对照组。所有对照组的寿命都在该品系的正常范围内：在实验1中，对照组寿命最短为40天，最长为53天；实验组的数据为81-91天；两组完全分开，实验组的最短寿命比对照组的最长寿命多28天，即大约2.5个完整的分布宽度——对零假设进行符号检验得出p < 2^(-20)，即最大p值为10^(-6)。实验2发现雄性和雌性的寿命没有差异；但30只对照组的最长寿命（雄性为60天，雌性为66天）再次远远短于两个实验组中60只果蝇的最短寿命，这强化了实验1的结果。尽管样本量相对较小，但结果是确凿的：所研究的养生法延长了黑腹果蝇品系俄勒冈-K的寿命。配方的复杂性表明涉及多种机制——值得进一步研究。
