Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Neuroimage. 2012 Jan 2;59(1):800-7. doi: 10.1016/j.neuroimage.2011.07.040. Epub 2011 Aug 2.
The five-factor model organizes personality traits into five factors: Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness. Measures of these personality traits predict people's behaviors and important outcomes of their lives. Therefore, understanding the neural correlates of these personality traits is important. This study assessed the relationships between white matter (WM) integrity and personality traits among 51 healthy participants using diffusion tensor imaging (DTI) and the revised NEO Personality Inventory (NEO-PI-R). Neuroticism correlated positively while Openness and Agreeableness correlated negatively with DTI mean diffusivity (MD) in the corona radiata and superior longitudinal fasciculus, tracts that interconnect prefrontal cortex (PFC), parietal cortex, and subcortical structures. Furthermore, Neuroticism correlated positively with MD in the anterior cingulum and uncinate fasciculus, tracts interconnecting PFC and amygdala. Openness correlated negatively with MD of WM adjacent to the dorsolateral PFC in both hemispheres. These findings suggest that greater Neuroticism associates with worse integrity of WM interconnecting extensive cortical and subcortical structures including the PFC and amygdala and that greater Openness associates with better integrity of WM interconnecting extensive cortical and subcortical structures including the dorsolateral PFC.
神经质、外向性、开放性、宜人性和尽责性。这些人格特质的测量可以预测人们的行为和生活的重要结果。因此，了解这些人格特质的神经相关性很重要。本研究使用弥散张量成像（DTI）和修订的 NEO 人格量表（NEO-PI-R）评估了 51 名健康参与者的白质（WM）完整性与人格特质之间的关系。神经质与放射冠和上纵束的弥散张量成像平均弥散度（MD）呈正相关，而开放性和宜人性与弥散张量成像 MD 呈负相关，这些束连接前额叶皮质（PFC）、顶叶皮质和皮质下结构。此外，神经质与 PFC 和杏仁核连接的前扣带束和钩束的 MD 呈正相关。开放性与双侧 PFC 背外侧 WM 相邻的 MD 呈负相关。这些发现表明，神经质程度越高，与包括前额叶皮质和杏仁核在内的广泛皮质和皮质下结构之间 WM 连接的完整性越差，而开放性程度越高，与包括 PFC 背外侧在内的广泛皮质和皮质下结构之间 WM 连接的完整性越好。
