Risch N
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510.
Genet Epidemiol. 1990;7(1):3-16; discussion 17-45. doi: 10.1002/gepi.1370070103.
Recent linkage findings for psychiatric disorders, in particular schizophrenia, manic-depression, and Alzheimer disease, have raised a number of important conceptual issues regarding the genetic etiology of these diseases, as well as the appropriate interpretation of linkage results in studying complex diseases. Perspectives on mode of inheritance, genetic heterogeneity, and phenotypic variation are given.
近期针对精神疾病，尤其是精神分裂症、躁郁症和阿尔茨海默病的连锁研究结果，引发了一系列关于这些疾病遗传病因的重要概念性问题，以及在研究复杂疾病时对连锁结果的恰当解读。文中给出了关于遗传方式、遗传异质性和表型变异的观点。
