白色念珠菌SRR1是一种假定的双组分反应调节基因，是应激适应、形态发生和毒力所必需的。
Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence.
作者信息
Desai Chirayu, Mavrianos John, Chauhan Neeraj
机构信息
Public Health Research Institute and Department of Microbiology and Molecular Genetics, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 225 Warren Street, Newark, NJ 07078, USA.
出版信息
Eukaryot Cell. 2011 Oct;10(10):1370-4. doi: 10.1128/EC.05188-11. Epub 2011 Aug 12.
Abstract
We report here the identification and characterization of a previously uncharacterized, two-component response regulator gene (orf19.5843) from Candida albicans. Because of its apparent functions in stress adaptation, we have named this gene SRR1 (stress response regulator 1). Disruption of SRR1 causes defects in hyphal development, reduced resistance to stress, and severe virulence attenuation in the mouse model of disseminated candidiasis.
摘要
我们在此报告对白色念珠菌中一个此前未被鉴定的双组分反应调节基因（orf19.5843）的鉴定与表征。由于其在应激适应中具有明显功能，我们将该基因命名为SRR1（应激反应调节因子1）。SRR1的缺失导致菌丝发育缺陷、对应激的抗性降低以及在播散性念珠菌病小鼠模型中严重的毒力减弱。
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