Department of Periodontics, Georgia Health Science University, Augusta, Georgia, USA.
Int J Oral Maxillofac Implants. 2011 Jul-Aug;26(4):731-8.
To evaluate osseointegration of a novel calcium phosphate (CaP)-coated titanium porous oxide implant surface.
Twenty adult male New Zealand White rabbits were used. Each animal received two titanium porous oxide-surfaced implants (benchmark control: TiUnite, Nobel Biocare) and two novel CaP-coated titanium porous oxide-surfaces implants; they were randomly allocated to contralateral tibia implant sites. The animals were sacrificed after 2 or 4 weeks, and tissues were evaluated histometrically.
Healing was generally uneventful. A removal torque analysis showed significantly higher mean (± SE) peak values for the control implants than for the test implants at 2 weeks (31.4 ± 2.5 Ncm versus 20.4 ± 1.8 Ncm) and 4 weeks (48.4 ± 5.5 Ncm versus 30.3 ± 3.9 Ncm). Light microscopy showed no significant differences in local bone density around control and test implants at 2 and 4 weeks (range, 85% to 91% within the thread area and 91% to 95% immediately outside the threads). At 2 weeks, bone-implant contact for control and test implants averaged 81.8% ± 2.8% and 75.7% ± 4.6%, respectively, and at 4 weeks the bone-implant contact values were 79.4% ± 2.8% and 73.5% ± 4.2%, respectively; these differences were not significant. Backscatter scanning electron microscopy also showed no significant differences in local bone density at control and test implants at 2 and 4 weeks (range, 55% to 72% within the thread area and 75% to 81% immediately outside the threads). At 2 weeks, bone-implant contact for control and test implants averaged 66.4% ± 2.9% and 61.5% ± 5.1%, respectively, and at 4 weeks mean values were 60.1% ± 4.2% and 53.3% ± 4.6% (differences not significant).
The results suggest that the novel CaP-coated surface effectively supports osseointegration.
评估新型钙磷（CaP）涂层钛多孔氧化植入物表面的骨整合情况。
使用 20 只成年雄性新西兰白兔。每只动物接受两个钛多孔氧化表面植入物（基准对照：TiUnite，诺贝尔生物公司）和两个新型 CaP 涂层钛多孔氧化表面植入物；它们被随机分配到对侧胫骨植入物部位。在 2 周和 4 周后，处死动物并进行组织学评估。
愈合情况总体顺利。去除扭矩分析显示，在 2 周和 4 周时，对照植入物的平均（± SE）峰值明显高于试验植入物，分别为 31.4 ± 2.5 Ncm 和 48.4 ± 5.5 Ncm，而试验植入物分别为 20.4 ± 1.8 Ncm 和 30.3 ± 3.9 Ncm。在 2 周和 4 周时，对照和试验植入物周围的局部骨密度无显著差异（螺纹区域内为 85%至 91%，螺纹外立即为 91%至 95%）。在 2 周时，对照和试验植入物的骨-植入物接触率分别为 81.8%±2.8%和 75.7%±4.6%，而在 4 周时，骨-植入物接触率分别为 79.4%±2.8%和 73.5%±4.2%；这些差异无统计学意义。背散射扫描电子显微镜也显示，在 2 周和 4 周时，对照和试验植入物周围的局部骨密度无显著差异（螺纹区域内为 55%至 72%，螺纹外立即为 75%至 81%）。在 2 周时，对照和试验植入物的骨-植入物接触率分别为 66.4%±2.9%和 61.5%±5.1%，而在 4 周时，平均分别为 60.1%±4.2%和 53.3%±4.6%（差异无统计学意义）。
结果表明，新型 CaP 涂层表面能有效支持骨整合。
