运用成年斑马鱼建立焦虑模型：概念综述。
Modeling anxiety using adult zebrafish: a conceptual review.
机构信息
Department of Pharmacology and Neuroscience Program, Tulane Neurophenotyping Platform, Zebrafish Neuroscience Research Consortium, Tulane University Medical School, 1430 Tulane Ave., New Orleans, LA 70112, USA.
出版信息
Neuropharmacology. 2012 Jan;62(1):135-43. doi: 10.1016/j.neuropharm.2011.07.037. Epub 2011 Aug 9.
Abstract
Zebrafish (Danio rerio) are rapidly emerging as a useful animal model in neurobehavioral research. Mounting evidence shows the suitability of zebrafish to model various aspects of anxiety-related states. Here, we evaluate established and novel approaches to uncover the molecular substrates, genetic pathways and neural circuits of anxiety using adult zebrafish. Experimental approaches to modeling anxiety in zebrafish include novelty-based paradigms, pharmacological and genetic manipulations, as well as innovative video-tracking, 3D-reconstructions, bioinformatics-based searchable databases and omics-based tools. Complementing traditional rodent models of anxiety, we provide a conceptual framework for the wider application of zebrafish and other aquatic models in anxiety research. This article is part of a Special Issue entitled 'Anxiety and Depression'.
摘要
斑马鱼（Danio rerio）作为神经行为研究中的一种有用的动物模型，正迅速崛起。越来越多的证据表明，斑马鱼适合模拟与焦虑相关状态的各个方面。在这里，我们使用成年斑马鱼来评估发现焦虑相关的分子基础、遗传途径和神经回路的已建立和新方法。在斑马鱼中进行焦虑建模的实验方法包括基于新颖性的范式、药理学和遗传学操作，以及创新的视频跟踪、3D 重建、基于生物信息学的可搜索数据库和基于组学的工具。除了传统的焦虑症啮齿动物模型外，我们还为更广泛地将斑马鱼和其他水生模型应用于焦虑症研究提供了一个概念框架。本文是题为“焦虑和抑郁”的特刊的一部分。
相似文献
1
Modeling anxiety using adult zebrafish: a conceptual review.运用成年斑马鱼建立焦虑模型：概念综述。
Neuropharmacology. 2012 Jan;62(1):135-43. doi: 10.1016/j.neuropharm.2011.07.037. Epub 2011 Aug 9.
2
Zebrafish models: do we have valid paradigms for depression?斑马鱼模型：我们有用于抑郁症的有效范例吗？
J Pharmacol Toxicol Methods. 2018 Nov-Dec;94(Pt 2):16-22. doi: 10.1016/j.vascn.2018.07.002. Epub 2018 Jul 18.
3
Imaging escape and avoidance behavior in zebrafish larvae.在斑马鱼幼鱼中观察逃避行为。
Rev Neurosci. 2011;22(1):63-73. doi: 10.1515/RNS.2011.008.
4
Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models.在成年斑马鱼行为模型中，通过药理学调节焦虑样表型。
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 1;35(6):1421-31. doi: 10.1016/j.pnpbp.2010.11.035. Epub 2010 Nov 29.
5
Behavioral measures of anxiety in zebrafish (Danio rerio).斑马鱼（Danio rerio）焦虑行为的测量。
Behav Brain Res. 2010 Mar 17;208(1):56-62. doi: 10.1016/j.bbr.2009.11.009. Epub 2009 Nov 5.
6
The influence of exercise on anxiety-like behavior in zebrafish (Danio rerio).运动对斑马鱼（Danio rerio）焦虑样行为的影响。
Behav Processes. 2018 Dec;157:638-644. doi: 10.1016/j.beproc.2018.04.006. Epub 2018 Apr 12.
7
Three- and bi-dimensional analyses of the shoaling behavior in zebrafish: Influence of modulators of anxiety-like responses.三种和二维分析斑马鱼的集群行为：焦虑样反应调节剂的影响。
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 30;102:109957. doi: 10.1016/j.pnpbp.2020.109957. Epub 2020 Apr 30.
8
Increase in environmental temperature affects exploratory behaviour, anxiety and social preference in Danio rerio.环境温度升高会影响斑马鱼的探索行为、焦虑和社交偏好。
Sci Rep. 2020 Mar 25;10(1):5385. doi: 10.1038/s41598-020-62331-1.
9
The behavioral effects of acute Δ⁹-tetrahydrocannabinol and heroin (diacetylmorphine) exposure in adult zebrafish.急性 Δ⁹-四氢大麻酚和海洛因（二乙酰吗啡）暴露对成年斑马鱼行为的影响。
Brain Res. 2014 Jan 16;1543:109-19. doi: 10.1016/j.brainres.2013.11.002. Epub 2013 Nov 8.
10
Three-dimensional neurophenotyping of adult zebrafish behavior.成年斑马鱼行为的三维神经表型分析。
PLoS One. 2011 Mar 7;6(3):e17597. doi: 10.1371/journal.pone.0017597.
引用本文的文献
1
Neurobiology of psilocybin: a comprehensive overview and comparative analysis of experimental models.裸盖菇素的神经生物学：实验模型的全面综述与比较分析
Front Syst Neurosci. 2025 Aug 5;19:1585367. doi: 10.3389/fnsys.2025.1585367. eCollection 2025.
2
Elevated IGFBP4 and Cognitive Impairment in a PTFE-Induced Mouse Model of Obstructive Sleep Apnea.聚四氟乙烯诱导的阻塞性睡眠呼吸暂停小鼠模型中IGFBP4升高与认知障碍
Int J Mol Sci. 2025 Aug 1;26(15):7423. doi: 10.3390/ijms26157423.
3
Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors.由III型代谢型谷氨酸受体介导的抑制作用调节缰核活动和防御行为。
Nat Commun. 2025 Aug 5;16(1):7187. doi: 10.1038/s41467-025-62115-z.
4
Food reward entrainment increases mealtime anxiety in goldfish via a ghrelin-dependent mechanism.食物奖励诱导通过一种依赖胃饥饿素的机制增加金鱼进食时的焦虑。
Sci Rep. 2025 Jul 30;15(1):27768. doi: 10.1038/s41598-025-13194-x.
5
Intranasal delivery of drugs to the central nervous system of adult zebrafish.向成年斑马鱼的中枢神经系统进行鼻内给药。
Lab Anim (NY). 2025 May;54(5):126-132. doi: 10.1038/s41684-025-01545-0. Epub 2025 Apr 30.
6
Behavioral and Biochemical Insights into the Therapeutic Potential of Mitocurcumin in a Zebrafish-Pentylenetetrazole (PTZ) Epilepsy Model.米托姜黄素在斑马鱼-戊四氮（PTZ）癫痫模型中治疗潜力的行为学和生物化学见解
Pharmaceuticals (Basel). 2025 Mar 7;18(3):382. doi: 10.3390/ph18030382.
7
The number of conspecific alarm substance donors notably influences the behavioural responses of zebrafish subjected to a traumatic stress procedure.同种警报物质供体的数量显著影响经历创伤应激程序的斑马鱼的行为反应。
Fish Physiol Biochem. 2025 Feb 26;51(2):55. doi: 10.1007/s10695-025-01468-0.
8
Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds.斑马鱼作为利用香豆素和基于香豆素的化合物生物活性的合适模型。
Int J Mol Sci. 2025 Feb 8;26(4):1444. doi: 10.3390/ijms26041444.
9
Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians.基于涡虫的计算物理化学性质和实验表型分析来区分神经活性药物类别。
PLoS One. 2025 Jan 30;20(1):e0315394. doi: 10.1371/journal.pone.0315394. eCollection 2025.
10
Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation.短暂接触（-）四氢大麻酚会影响斑马鱼胚胎的运动，这种影响会持续到下一代。
Sci Rep. 2025 Jan 16;15(1):2203. doi: 10.1038/s41598-024-82353-3.
本文引用的文献
1
Experimental models for anxiolytic drug discovery in the era of omes and omics.在omes 和 omics 时代用于发现抗焦虑药物的实验模型。
Expert Opin Drug Discov. 2011 Jul;6(7):755-69. doi: 10.1517/17460441.2011.586028. Epub 2011 Jun 6.
2
Fear, anxiety, and control in the zebrafish.斑马鱼的恐惧、焦虑和控制。
Dev Neurobiol. 2012 Mar;72(3):395-403. doi: 10.1002/dneu.20873.
3
Circuit neuroscience in zebrafish.斑马鱼的电路神经科学。
Curr Biol. 2010 Apr 27;20(8):R371-81. doi: 10.1016/j.cub.2010.02.039.
4
Zebrafish models to study drug abuse-related phenotypes.斑马鱼模型研究与药物滥用相关的表型。
Rev Neurosci. 2011;22(1):95-105. doi: 10.1515/RNS.2011.011.
5
Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol.抗焦虑药在斑马鱼中的作用：苯二氮䓬类、丁螺环酮和乙醇之间的相似性和差异。
Pharmacol Biochem Behav. 2011 Sep;99(3):480-6. doi: 10.1016/j.pbb.2011.04.021. Epub 2011 May 5.
6
Differences in spatio-temporal behavior of zebrafish in the open tank paradigm after a short-period confinement into dark and bright environments.短期限制在黑暗和明亮环境后，开放式鱼缸范式中斑马鱼时空行为的差异。
PLoS One. 2011 May 2;6(5):e19397. doi: 10.1371/journal.pone.0019397.
7
Acute stress disrupts performance of zebrafish in the cued and spatial memory tests: the utility of fish models to study stress-memory interplay.急性应激会干扰斑马鱼在线索记忆和空间记忆测试中的表现：鱼类模型在研究应激与记忆相互作用方面的效用。
Behav Processes. 2011 Jun;87(2):224-30. doi: 10.1016/j.beproc.2011.04.004. Epub 2011 May 3.
8
Anxiogenic behaviour induced by 17α-ethynylestradiol in male guppies (Poecilia reticulata).17α-乙炔基雌二醇诱导雄性孔雀鱼（Poecilia reticulata）产生焦虑行为。
Fish Physiol Biochem. 2011 Dec;37(4):911-8. doi: 10.1007/s10695-011-9488-x. Epub 2011 May 3.
9
Behavioral effects of MDMA ('ecstasy') on adult zebrafish.摇头丸（“迷幻药”）对成年斑马鱼的行为影响。
Behav Pharmacol. 2011 Jun;22(3):275-80. doi: 10.1097/FBP.0b013e328345f758.
10
Three-dimensional neurophenotyping of adult zebrafish behavior.成年斑马鱼行为的三维神经表型分析。
PLoS One. 2011 Mar 7;6(3):e17597. doi: 10.1371/journal.pone.0017597.
Zotero 插件