Department of Pharmacology and Neuroscience Program, Tulane Neurophenotyping Platform, Zebrafish Neuroscience Research Consortium, Tulane University Medical School, 1430 Tulane Ave., New Orleans, LA 70112, USA.
Neuropharmacology. 2012 Jan;62(1):135-43. doi: 10.1016/j.neuropharm.2011.07.037. Epub 2011 Aug 9.
Zebrafish (Danio rerio) are rapidly emerging as a useful animal model in neurobehavioral research. Mounting evidence shows the suitability of zebrafish to model various aspects of anxiety-related states. Here, we evaluate established and novel approaches to uncover the molecular substrates, genetic pathways and neural circuits of anxiety using adult zebrafish. Experimental approaches to modeling anxiety in zebrafish include novelty-based paradigms, pharmacological and genetic manipulations, as well as innovative video-tracking, 3D-reconstructions, bioinformatics-based searchable databases and omics-based tools. Complementing traditional rodent models of anxiety, we provide a conceptual framework for the wider application of zebrafish and other aquatic models in anxiety research. This article is part of a Special Issue entitled 'Anxiety and Depression'.
斑马鱼（Danio rerio）作为神经行为研究中的一种有用的动物模型，正迅速崛起。越来越多的证据表明，斑马鱼适合模拟与焦虑相关状态的各个方面。在这里，我们使用成年斑马鱼来评估发现焦虑相关的分子基础、遗传途径和神经回路的已建立和新方法。在斑马鱼中进行焦虑建模的实验方法包括基于新颖性的范式、药理学和遗传学操作，以及创新的视频跟踪、3D 重建、基于生物信息学的可搜索数据库和基于组学的工具。除了传统的焦虑症啮齿动物模型外，我们还为更广泛地将斑马鱼和其他水生模型应用于焦虑症研究提供了一个概念框架。本文是题为“焦虑和抑郁”的特刊的一部分。
