分子的应答与响应：细菌小RNA的生理学
Molecular call and response: the physiology of bacterial small RNAs.
作者信息
Richards Gregory R, Vanderpool Carin K
机构信息
Department of Microbiology, University of Illinois, Urbana, IL 61801, USA.
出版信息
Biochim Biophys Acta. 2011 Oct;1809(10):525-31. doi: 10.1016/j.bbagrm.2011.07.013. Epub 2011 Aug 6.
Abstract
The vital role of bacterial small RNAs (sRNAs) in cellular regulation is now well-established. Although many diverse mechanisms by which sRNAs bring about changes in gene expression have been thoroughly described, comparatively less is known about their biological roles and effects on cell physiology. Nevertheless, for some sRNAs, insight has been gained into the intricate regulatory interplay that is required to sense external environmental and internal metabolic cues and turn them into physiological outcomes. Here, we review examples of regulation by selected sRNAs, emphasizing signals and regulators required for sRNA expression, sRNA regulatory targets, and the resulting consequences for the cell. We highlight sRNAs involved in regulation of the processes of iron homeostasis (RyhB, PrrF, and FsrA) and carbon metabolism (Spot 42, CyaR, and SgrS).
摘要
细菌小RNA（sRNA）在细胞调控中的重要作用现已得到充分证实。尽管已经详细描述了sRNA引起基因表达变化的多种不同机制，但对于它们的生物学作用以及对细胞生理学的影响却知之甚少。然而，对于一些sRNA，我们已经深入了解了其复杂的调控相互作用，即感知外部环境和内部代谢信号并将其转化为生理结果所需的相互作用。在这里，我们回顾了选定sRNA的调控实例，重点强调了sRNA表达所需的信号和调节因子、sRNA调控靶点以及对细胞产生的后果。我们重点介绍了参与铁稳态（RyhB、PrrF和FsrA）和碳代谢（Spot 42、CyaR和SgrS）过程调控的sRNA。
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