钒酸盐对糖尿病大鼠的胰岛素样作用。
Insulinic actions of vanadate in diabetic rats.
作者信息
Sekar N, Kanthasamy A, William S, Subramanian S, Govindasamy S
机构信息
Department of Biochemistry, University of Madras, India.
出版信息
Pharmacol Res. 1990 Mar-Apr;22(2):207-17. doi: 10.1016/1043-6618(90)90717-r.
Oral administration of sodium orthovanadate (0.3 mg/dl) normalizes blood glucose and reduces glycosylated HbA1 levels in streptozotocin induced diabetic rats without any increase in the serum insulin levels. However, diabetic condition reappears after withdrawal of vanadate. Assays of carbohydrate metabolizing enzymes clearly indicate that vanadate activates the glycolysis, glycogenesis and depresses the glycogenolysis and gluconeogenesis in diabetic rats. These results demonstrate that vanadate substitutes insulin action in chronic experimental diabetics.
口服原钒酸钠（0.3毫克/分升）可使链脲佐菌素诱导的糖尿病大鼠的血糖正常化，并降低糖化血红蛋白A1水平，而血清胰岛素水平无任何升高。然而，停用钒酸盐后糖尿病状况会再次出现。碳水化合物代谢酶的测定清楚地表明，钒酸盐可激活糖尿病大鼠的糖酵解、糖原合成，并抑制糖原分解和糖异生。这些结果表明，钒酸盐可替代慢性实验性糖尿病患者体内胰岛素的作用。
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