Liu Yang, Jin Jian-qiu, Yuan Zhen-fang, Liu Xiao Song, Cao Jie, Guo Xiao-hui, Liu Hong-wei
Department of TCM and Oral Medicine, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Aug 18;43(4):596-9.
To study the relationship between type 2 diabetes mellitus (T2DM) and oral lichen planus (OLP) by detecting the level of salivary tumor necrosis factor (TNF-α) and interlukin-6 (IL-6).
Subjects were divided into 4 groups: T2DM/OLP group 29 patients, T2DM group 39 patients, OLP group 21 patients, and control group 43 individuals. The salivary interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) were detected by enzyme-linked immuno sorbent assay (ELISA).
(1) The level of salivary IL-6 in patients with T2DM/OLP [(12.30 ± 16.03) ng/L] was significantly higher than those in T2DM [(6.29 ± 5.91) ng/L] and OLP groups [(3.64 ± 4.47) ng/L], P<0.05. The level of salivary IL-6 was significantly lower in OLP group [(3.64 ± 4.47) ng/L] than in control group [(7.91 ± 4.05) ng/L], P<0.001. The level of salivary TNF-α in T2DM group [(8.80 ± 8.41) ng/L] was significantly lower than those in OLP [(14.02 ± 9.65) ng/L] and control groups [(15.02 ± 6.13) ng/L], P<0.05. (2) The level of salivary TNF-α is significantly negative correlated with pH value of saliva in T2DM/OLP group(r=-0.593, P<0.01);The level of salivary TNF-α and IL-6 are significantly positive correlated with waistline in control group(r=0.312,P=0.05).(3) The levels of salivary IL-6 and TNF-α were positively related to OLP clinical type, P<0.05. (4)When OLP played an overlying role on T2DM, the level of TNF-α was weakened and that of IL-6 was strengthened.
When T2DM and OLP are in concurrence,there is a synergistic effect,and the secretion of IL-6 increases markedly; The level of salivary TNF-α is associated with local oral environment.
通过检测唾液肿瘤坏死因子（TNF-α）和白细胞介素-6（IL-6）水平，研究2型糖尿病（T2DM）与口腔扁平苔藓（OLP）之间的关系。
将受试者分为4组：T2DM/OLP组29例患者，T2DM组39例患者，OLP组21例患者，对照组43例个体。采用酶联免疫吸附测定法（ELISA）检测唾液白细胞介素-6（IL-6）和肿瘤坏死因子（TNF-α）。
（1）T2DM/OLP患者唾液IL-6水平[（12.30±16.03）ng/L]显著高于T2DM患者[（6.29±5.91）ng/L]和OLP组患者[（3.64±4.47）ng/L]，P<0.05。OLP组患者唾液IL-6水平[（3.64±4.47）ng/L]显著低于对照组[（7.91±4.05）ng/L]，P<0.001。T2DM组患者唾液TNF-α水平[（8.80±8.41）ng/L]显著低于OLP组[（14.02±9.65）ng/L]和对照组[（15.02±6.13）ng/L]，P<0.05。（2）T2DM/OLP组唾液TNF-α水平与唾液pH值呈显著负相关（r=-0.593，P<0.01）；对照组唾液TNF-α和IL-6水平与腰围呈显著正相关（r=0.312，P=0.05）。（3）唾液IL-6和TNF-α水平与OLP临床类型呈正相关，P<0.05。（4）当OLP叠加于T2DM之上时，TNF-α水平减弱，IL-6水平增强。
T2DM与OLP并存时存在协同作用，IL-6分泌明显增加；唾液TNF-α水平与口腔局部环境有关。
