Mozaffari Hamid Reza, Sharifi Roohollah, Sadeghi Masoud
Department of Oral Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Cent Eur J Immunol. 2018;43(1):103-108. doi: 10.5114/ceji.2018.74880. Epub 2018 Mar 30.
Interleukin-6 (IL-6) is a cytokine that contributes to the pathogenesis of oral lichen planus (OLP). The aim of this meta-analysis study is the evaluation of IL-6 levels in the serum and saliva of patients with OLP compared with healthy controls. We searched the studies in 5 databases: PubMed/Medline, Scopus, ScienceDirect, Web of Science, and Cochrane Library, from 1983 to Oct 31, 2016. Eleven studies were analysed for the meta-analysis study. The reviewers independently evaluated the quality of each included study using the Newcastle-Ottawa Quality Assessment Scale (NOS). A random-effects meta-analysis, using Comprehensive Meta-Analysis software version 2.0, was used to reflect the variation in studies. Heterogeneity between estimates was evaluated by the Q and I statistics and for the Q statistic; heterogeneity was considered for p < 0.1. Eleven studies included 529 OLP patients and 333 healthy controls. The review identified two different biomaterials used for IL-6 assays: saliva and serum. The mean quality score of eleven studies was 7 (high quality). Estimates pooled from 6 studies showed significant high saliva IL-6 levels in OLP patients compared with healthy controls (the standardised difference in means (SDM) = 4.534, 95% CI = 1.915-7.153, p = 0.001). Also, estimates pooled from 7 studies showed significantly high serum IL-6 levels in OLP patients compared with healthy controls (SDM = 1.482, 95% CI = 0.524-2.439, p = 0.002). The higher levels of IL-6 in saliva compared with serum suggest that measurement of this marker in saliva may be more useful than serum for diagnostic and therapeutic aims.
白细胞介素-6（IL-6）是一种细胞因子，参与口腔扁平苔藓（OLP）的发病机制。本荟萃分析研究的目的是评估与健康对照相比，OLP患者血清和唾液中的IL-6水平。我们检索了1983年至2016年10月31日期间5个数据库中的研究：PubMed/Medline、Scopus、ScienceDirect、Web of Science和Cochrane图书馆。对11项研究进行了荟萃分析。 reviewers使用纽卡斯尔-渥太华质量评估量表（NOS）独立评估每项纳入研究的质量。使用综合荟萃分析软件2.0进行随机效应荟萃分析，以反映研究中的差异。通过Q和I统计量评估估计值之间的异质性，对于Q统计量，当p<0.1时考虑异质性。11项研究包括529名OLP患者和333名健康对照。该综述确定了用于IL-6检测的两种不同生物材料：唾液和血清。11项研究的平均质量评分为7（高质量）。来自6项研究的汇总估计显示，与健康对照相比，OLP患者唾液中的IL-6水平显著升高（平均标准化差异（SDM）=4.534，95%CI=1.915-7.153，p=0.001）。此外，来自7项研究的汇总估计显示，与健康对照相比，OLP患者血清中的IL-6水平显著升高（SDM=1.482，95%CI=0.524-2.439，p=0.002）。与血清相比，唾液中IL-6水平更高表明，对于诊断和治疗目的，检测唾液中的该标志物可能比检测血清更有用。
