Department of Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust, Lier, Norway. paul.moller @ vestreviken.no
Psychopathology. 2011;44(6):386-90. doi: 10.1159/000325173. Epub 2011 Aug 17.
The growing research focus on early detection of schizophrenia has fostered an increasing interest in the nonpsychotic experiential anomalies that may antedate schizophrenia spectrum disorders and assist early differential diagnosis. The Examination of Anomalous Self-Experience (EASE) is a phenomenologically inspired checklist, specifically designed to support the comprehensive assessment of these characteristic subjective experiences.
To assess the interrater reliability of the EASE.
Twenty-five first-episode psychosis (FEP) patients were interviewed with the EASE. Videotaped interviews were blindly reevaluated. Internal consistency, overall interrater correlation and item interrater agreement (Cohen's kappa) were estimated.
The EASE showed good to excellent internal consistency across the two raters (Cronbach's alpha above 0.87) and an overall inter-rater correlation above 0.80 (Spearman's rho, p < 0.001). The average kappa of the EASE was 0.65, ranging from 0.51 to 0.73 over the 5 domains; kappa values at an item level were very good in 9 items, good in 20 items, moderate in 11 items and fair in 4 items.
The EASE provides a reliable and internally consistent clinical tool for the assessment of subjective experience in FEP patients, suggesting that this instrument could usefully supplement standard clinical assessments during the onset phase of psychosis.
对精神分裂症早期检测的研究日益增多，这促使人们对可能先于精神分裂症谱系障碍出现并有助于早期鉴别诊断的非精神病性体验异常产生了越来越大的兴趣。体验异常检查表（EASE）是一种受现象学启发的检查表，专门用于支持对这些特征性主观体验的全面评估。
评估 EASE 的评分者间信度。
对 25 例首发精神病（FEP）患者进行 EASE 访谈。对录像访谈进行盲法重新评估。评估内部一致性、总体评分者间相关性和项目评分者间一致性（Cohen's kappa）。
EASE 在两位评分者之间表现出良好到优秀的内部一致性（Cronbach's alpha 均大于 0.87），总体评分者间相关性大于 0.80（Spearman's rho，p<0.001）。EASE 的平均 kappa 值为 0.65，5 个领域的 kappa 值范围为 0.51 至 0.73；5 个领域中有 9 个项目的 kappa 值为极好，20 个项目的 kappa 值为好，11 个项目的 kappa 值为中等，4 个项目的 kappa 值为一般。
EASE 为评估 FEP 患者的主观体验提供了一种可靠且内部一致的临床工具，表明该工具在精神病发病期可有助于补充标准临床评估。
