Altieri M, Bogema S, Schwartz R H
Department of Emergency Medicine, Fairfax Hospital, Falls Church, Virginia 22046.
Ann Emerg Med. 1990 May;19(5):577-9. doi: 10.1016/s0196-0644(05)82193-6.
The combination of tetracaine, adrenalin, and cocaine (TAC) has become increasingly popular as a topical anesthetic for the suturing of simple skin lacerations. The purpose of this study was to determine the effects of TAC on a urine drug test for cocaine. On the morning after the use of TAC, 14 of 18 patients (78%) studied had positive screening tests for benzoylecgonine (cocaine metabolite) by the enzyme multiplied immunoassay test (EMIT) method. All specimens also were analyzed by gas chromatography and mass spectrometry, the reference standard for analysis of drugs of abuse in urine, and 15 of the specimens (83%) were positive. Four of 18 positive specimens (22%) still had positive EMIT drug screens on the morning of the next day, an average of 36 hours after use of TAC. We recommend that physicians who use TAC solution as a local anesthetic caution their patients that they may fail a urine drug screen for cocaine if they are tested within 36 to 48 hours of the administration of the use of TAC.
丁卡因、肾上腺素和可卡因（TAC）的组合作为一种用于简单皮肤裂伤缝合的局部麻醉剂越来越受欢迎。本研究的目的是确定TAC对可卡因尿液药物检测的影响。在使用TAC后的早晨，18名接受研究的患者中有14名（78%）通过酶联免疫分析试验（EMIT）方法对苯甲酰芽子碱（可卡因代谢物）的筛查呈阳性。所有标本也通过气相色谱和质谱法进行了分析，这是尿液中滥用药物分析的参考标准，其中15个标本（83%）呈阳性。18个阳性标本中有4个（22%）在第二天早晨，即使用TAC后平均36小时，EMIT药物筛查仍呈阳性。我们建议使用TAC溶液作为局部麻醉剂的医生提醒他们的患者，如果在使用TAC后36至48小时内进行检测，他们可能会在可卡因尿液药物筛查中出现阳性结果。
